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Integrated systems biology identifies disruptions in mitochondrial function and metabolism as key contributors to heart failure with preserved ejection fraction (HFpEF).
Gibb AA, LaPenna K, Gaspar RB, Latchman NR, Tan Y, Choya-Foces C, Doiron JE, Li Z, Xia H, Lazaropoulos MP, Conwell M, Sharp TE 3rd, Goodchild TT, Lefer DJ, Elrod JW. Gibb AA, et al. Among authors: lefer dj. bioRxiv [Preprint]. 2024 Oct 25:2024.10.25.619450. doi: 10.1101/2024.10.25.619450. bioRxiv. 2024. PMID: 39484400 Free PMC article. Preprint.
Sustained release nitrite therapy results in myocardial protection in a porcine model of metabolic syndrome with peripheral vascular disease.
Bradley JM, Islam KN, Polhemus DJ, Donnarumma E, Brewster LP, Tao YX, Goodchild TT, Lefer DJ. Bradley JM, et al. Among authors: lefer dj. Am J Physiol Heart Circ Physiol. 2015 Jul 15;309(2):H305-17. doi: 10.1152/ajpheart.00163.2015. Epub 2015 May 8. Am J Physiol Heart Circ Physiol. 2015. PMID: 25957218 Free PMC article.
A novel fibroblast activation inhibitor attenuates left ventricular remodeling and preserves cardiac function in heart failure.
Bradley JM, Spaletra P, Li Z, Sharp TE 3rd, Goodchild TT, Corral LG, Fung L, Chan KWH, Sullivan RW, Swindlehurst CA, Lefer DJ. Bradley JM, et al. Among authors: lefer dj. Am J Physiol Heart Circ Physiol. 2018 Sep 1;315(3):H563-H570. doi: 10.1152/ajpheart.00603.2017. Epub 2018 Jun 27. Am J Physiol Heart Circ Physiol. 2018. PMID: 29949382 Free PMC article.
268 results