Zacharewski T - Search Results

1

2,3,7,8-Tetrachlorodibenzo- p -dioxin (TCDD) elicited dose-dependent shifts in the murine urinary metabolome associated with hepatic AHR-mediated differential gene expression.

Sink WJ, Fling R, Yilmaz A, Nault R, Goniwiecha D, Harkema JR, Graham SF, Zacharewski T. Sink WJ, et al. Among authors: zacharewski t. bioRxiv [Preprint]. 2024 Oct 25:2024.10.22.619714. doi: 10.1101/2024.10.22.619714. bioRxiv. 2024. PMID: 39484576 Free PMC article. Preprint.

2

Inhibition of the urea cycle by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin increases serum ammonia levels in mice.

Cholico GN, Fling RR, Sink WJ, Nault R, Zacharewski T. Cholico GN, et al. Among authors: zacharewski t. J Biol Chem. 2024 Jan;300(1):105500. doi: 10.1016/j.jbc.2023.105500. Epub 2023 Nov 25. J Biol Chem. 2024. PMID: 38013089 Free PMC article.

3

Consequences of reprogramming acetyl-CoA metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse liver.

Cholico GN, Orlowska K, Fling RR, Sink WJ, Zacharewski NA, Fader KA, Nault R, Zacharewski T. Cholico GN, et al. Among authors: zacharewski t. Sci Rep. 2023 Mar 13;13(1):4138. doi: 10.1038/s41598-023-31087-9. Sci Rep. 2023. PMID: 36914879 Free PMC article.

4

Generative modeling of single-cell gene expression for dose-dependent chemical perturbations.

Kana O, Nault R, Filipovic D, Marri D, Zacharewski T, Bhattacharya S. Kana O, et al. Among authors: zacharewski t. Patterns (N Y). 2023 Aug 11;4(8):100817. doi: 10.1016/j.patter.2023.100817. eCollection 2023 Aug 11. Patterns (N Y). 2023. PMID: 37602218 Free PMC article.

5

A Case for Accelerating Standards to Achieve the FAIR Principles of Environmental Health Research Experimental Data.

Nault R, Cave MC, Ludewig G, Moseley HNB, Pennell KG, Zacharewski T. Nault R, et al. Among authors: zacharewski t. Environ Health Perspect. 2023 Jun;131(6):65001. doi: 10.1289/EHP11484. Epub 2023 Jun 23. Environ Health Perspect. 2023. PMID: 37352010 Free PMC article.

6

Disruption of canonical AHR-mediated induction of hepatocyte PKM2 expression compromises antioxidant defenses and increases TCDD-induced hepatotoxicity.

Orlowska K, Nault R, Ara J, LaPres JJ, Harkema J, Demireva EY, Xie H, Wilson RH, Bradfield CA, Yap D, Joshi A, Elferink CJ, Zacharewski T. Orlowska K, et al. Among authors: zacharewski t. Redox Biol. 2024 Nov;77:103405. doi: 10.1016/j.redox.2024.103405. Epub 2024 Oct 22. Redox Biol. 2024. PMID: 39490313 Free article.

7

Cell-specific AHR-driven differential gene expression in the mouse liver cell following acute TCDD exposure.

Cholico GN, Nault R, Zacharewski T. Cholico GN, et al. Among authors: zacharewski t. BMC Genomics. 2024 Aug 28;25(1):809. doi: 10.1186/s12864-024-10730-3. BMC Genomics. 2024. PMID: 39198768 Free PMC article.

8

Characterizing the impact of simvastatin co-treatment of cell specific TCDD-induced gene expression and systemic toxicity.

Jurgelewicz A, Nault R, Harkema J, Zacharewski TR, LaPres JJ. Jurgelewicz A, et al. Among authors: zacharewski tr. Sci Rep. 2023 Oct 3;13(1):16598. doi: 10.1038/s41598-023-42972-8. Sci Rep. 2023. PMID: 37789023 Free PMC article.

9

Cystine/Glutamate Xc^- Antiporter Induction Compensates for Transsulfuration Pathway Repression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Ensure Cysteine for Hepatic Glutathione Biosynthesis.

Orlowska K, Fling RR, Nault R, Schilmiller AL, Zacharewski TR. Orlowska K, et al. Among authors: zacharewski tr. Chem Res Toxicol. 2023 Jun 19;36(6):900-915. doi: 10.1021/acs.chemrestox.3c00017. Epub 2023 May 15. Chem Res Toxicol. 2023. PMID: 37184393 Free PMC article.

10

A Physiologically Based Pharmacokinetic (PBPK) Modeling Framework for Mixtures of Dioxin-like Compounds.

Liu R, Zacharewski TR, Conolly RB, Zhang Q. Liu R, et al. Among authors: zacharewski tr. Toxics. 2022 Nov 17;10(11):700. doi: 10.3390/toxics10110700. Toxics. 2022. PMID: 36422908 Free PMC article.

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