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Development of compact transcriptional effectors using high-throughput measurements in diverse contexts.
Tycko J, Van MV, Aradhana, DelRosso N, Ye H, Yao D, Valbuena R, Vaughan-Jackson A, Xu X, Ludwig C, Spees K, Liu K, Gu M, Khare V, Mukund AX, Suzuki PH, Arana S, Zhang C, Du PP, Ornstein TS, Hess GT, Kamber RA, Qi LS, Khalil AS, Bintu L, Bassik MC. Tycko J, et al. Among authors: liu k. Nat Biotechnol. 2024 Nov 1. doi: 10.1038/s41587-024-02442-6. Online ahead of print. Nat Biotechnol. 2024. PMID: 39487265
Pathogenic or benign?
Du PP, Liu K, Bassik MC, Hess GT. Du PP, et al. Among authors: liu k. Nat Biotechnol. 2022 Jun;40(6):834-836. doi: 10.1038/s41587-022-01333-y. Nat Biotechnol. 2022. PMID: 35578021 No abstract available.
Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis.
Kamber RA, Nishiga Y, Morton B, Banuelos AM, Barkal AA, Vences-Catalán F, Gu M, Fernandez D, Seoane JA, Yao D, Liu K, Lin S, Spees K, Curtis C, Jerby-Arnon L, Weissman IL, Sage J, Bassik MC. Kamber RA, et al. Among authors: liu k. Nature. 2021 Sep;597(7877):549-554. doi: 10.1038/s41586-021-03879-4. Epub 2021 Sep 8. Nature. 2021. PMID: 34497417 Free PMC article.
An SLC12A9-dependent ion transport mechanism maintains lysosomal osmolarity.
Levin-Konigsberg R, Mitra K, Spees K, Nigam A, Liu K, Januel C, Hivare P, Arana SM, Prolo LM, Kundaje A, Leonetti MD, Krishnan Y, Bassik MC. Levin-Konigsberg R, et al. Among authors: liu k. Dev Cell. 2025 Jan 20;60(2):220-235.e7. doi: 10.1016/j.devcel.2024.10.003. Epub 2024 Oct 29. Dev Cell. 2025. PMID: 39476838
Cell volume expansion and local contractility drive collective invasion of the basement membrane in breast cancer.
Chang J, Saraswathibhatla A, Song Z, Varma S, Sanchez C, Alyafei NHK, Indana D, Slyman R, Srivastava S, Liu K, Bassik MC, Marinkovich MP, Hodgson L, Shenoy V, West RB, Chaudhuri O. Chang J, et al. Among authors: liu k. Nat Mater. 2024 May;23(5):711-722. doi: 10.1038/s41563-023-01716-9. Epub 2023 Nov 13. Nat Mater. 2024. PMID: 37957268 Free PMC article.
An expanded universe of cancer targets.
Hahn WC, Bader JS, Braun TP, Califano A, Clemons PA, Druker BJ, Ewald AJ, Fu H, Jagu S, Kemp CJ, Kim W, Kuo CJ, McManus M, B Mills G, Mo X, Sahni N, Schreiber SL, Talamas JA, Tamayo P, Tyner JW, Wagner BK, Weiss WA, Gerhard DS; Cancer Target Discovery and Development Network. Hahn WC, et al. Cell. 2021 Mar 4;184(5):1142-1155. doi: 10.1016/j.cell.2021.02.020. Cell. 2021. PMID: 33667368 Free PMC article. Review.
SLC12A9 is a lysosome-detoxifying ammonium - chloride co-transporter.
Levin-Konigsberg R, Mitra K, Nigam A, Spees K, Hivare P, Liu K, Kundaje A, Krishnan Y, Bassik MC. Levin-Konigsberg R, et al. Among authors: liu k. bioRxiv [Preprint]. 2023 May 22:2023.05.22.541801. doi: 10.1101/2023.05.22.541801. bioRxiv. 2023. PMID: 37292735 Free PMC article. Preprint.
Deterministic evolution and stringent selection during preneoplasia.
Karlsson K, Przybilla MJ, Kotler E, Khan A, Xu H, Karagyozova K, Sockell A, Wong WH, Liu K, Mah A, Lo YH, Lu B, Houlahan KE, Ma Z, Suarez CJ, Barnes CP, Kuo CJ, Curtis C. Karlsson K, et al. Among authors: liu k. Nature. 2023 Jun;618(7964):383-393. doi: 10.1038/s41586-023-06102-8. Epub 2023 May 31. Nature. 2023. PMID: 37258665 Free PMC article.
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