Lechtenberg BC - Search Results

1

Lipidation and PEGylation strategies to prolong the in vivo half-life of a nanomolar EphA4 receptor antagonist.

Gomez-Soler M, Olson EJ, Rubio de la Torre E, Zhao C, Lamberto I, Flood DT, Danho W, Lechtenberg BC, Riedl SJ, Dawson PE, Pasquale EB. Gomez-Soler M, et al. Among authors: lechtenberg bc. Eur J Med Chem. 2023 Oct 16;262:115876. doi: 10.1016/j.ejmech.2023.115876. Online ahead of print. Eur J Med Chem. 2023. PMID: 39491430

2

Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor.

Lamberto I, Lechtenberg BC, Olson EJ, Mace PD, Dawson PE, Riedl SJ, Pasquale EB. Lamberto I, et al. Among authors: lechtenberg bc. ACS Chem Biol. 2014 Dec 19;9(12):2787-95. doi: 10.1021/cb500677x. Epub 2014 Oct 14. ACS Chem Biol. 2014. PMID: 25268696 Free PMC article.

3

Modifications of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor To Achieve High Plasma Stability.

Olson EJ, Lechtenberg BC, Zhao C, Rubio de la Torre E, Lamberto I, Riedl SJ, Dawson PE, Pasquale EB. Olson EJ, et al. Among authors: lechtenberg bc. ACS Med Chem Lett. 2016 Jun 25;7(9):841-6. doi: 10.1021/acsmedchemlett.6b00132. eCollection 2016 Sep 8. ACS Med Chem Lett. 2016. PMID: 27660688 Free PMC article.

4

Lipidation and PEGylation Strategies to Prolong the in Vivo Half-Life of a Nanomolar EphA4 Receptor Antagonist.

Gomez-Soler M, Olson EJ, de la Torre ER, Zhao C, Lamberto I, Flood DT, Danho W, Lechtenberg BC, Riedl SJ, Dawson PE, Pasquale EB. Gomez-Soler M, et al. Among authors: lechtenberg bc. Eur J Med Chem. 2023 Dec 15;262:115876. doi: 10.1016/j.ejmech.2023.115876. Epub 2023 Oct 16. Eur J Med Chem. 2023. PMID: 38523699

5

Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors.

Lechtenberg BC, Mace PD, Sessions EH, Williamson R, Stalder R, Wallez Y, Roth GP, Riedl SJ, Pasquale EB. Lechtenberg BC, et al. ACS Med Chem Lett. 2017 Jun 12;8(7):726-731. doi: 10.1021/acsmedchemlett.7b00127. eCollection 2017 Jul 13. ACS Med Chem Lett. 2017. PMID: 28740606 Free PMC article.

6

Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.

Gomez-Soler M, Petersen Gehring M, Lechtenberg BC, Zapata-Mercado E, Hristova K, Pasquale EB. Gomez-Soler M, et al. Among authors: lechtenberg bc. J Biol Chem. 2019 May 31;294(22):8791-8805. doi: 10.1074/jbc.RA119.008213. Epub 2019 Apr 23. J Biol Chem. 2019. PMID: 31015204 Free PMC article.

7

A cancer mutation promotes EphA4 oligomerization and signaling by altering the conformation of the SAM domain.

Light TP, Gomez-Soler M, Wang Z, Karl K, Zapata-Mercado E, Gehring MP, Lechtenberg BC, Pogorelov TV, Hristova K, Pasquale EB. Light TP, et al. Among authors: lechtenberg bc. J Biol Chem. 2021 Jul;297(1):100876. doi: 10.1016/j.jbc.2021.100876. Epub 2021 Jun 15. J Biol Chem. 2021. PMID: 34139238 Free PMC article.

8

Rosetta Stone of NLR Innate Immunity.

Lechtenberg BC, Riedl SJ. Lechtenberg BC, et al. Trends Biochem Sci. 2016 Jan;41(1):6-8. doi: 10.1016/j.tibs.2015.11.008. Epub 2015 Nov 26. Trends Biochem Sci. 2016. PMID: 26631419 Free PMC article.

9

Ligands with different dimeric configurations potently activate the EphA2 receptor and reveal its potential for biased signaling.

Gomez-Soler M, Gehring MP, Lechtenberg BC, Zapata-Mercado E, Ruelos A, Matsumoto MW, Hristova K, Pasquale EB. Gomez-Soler M, et al. Among authors: lechtenberg bc. iScience. 2022 Feb 4;25(3):103870. doi: 10.1016/j.isci.2022.103870. eCollection 2022 Mar 18. iScience. 2022. PMID: 35243233 Free PMC article.

10

Structural mechanisms in NLR inflammasome signaling.

Lechtenberg BC, Mace PD, Riedl SJ. Lechtenberg BC, et al. Curr Opin Struct Biol. 2014 Dec;29:17-25. doi: 10.1016/j.sbi.2014.08.011. Epub 2014 Sep 15. Curr Opin Struct Biol. 2014. PMID: 25201319 Free PMC article. Review.

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