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Lesional senescent CD4+ T cells mediate bystander cytolysis and contribute to the skin pathology of human cutaneous leishmaniasis.
Covre LP, Fantecelle CH, Garcia de Moura R, Oliveira Lopes P, Sarmento IV, Freire-de-Lima CG, Decote-Ricardo D, de Matos Guedes HL, da Fonsceca-Martins AM, de Carvalho LP, de Carvalho EM, Mosser DM, Falqueto A, Akbar AN, Gomes DCO. Covre LP, et al. Among authors: gomes dco. Front Immunol. 2024 Oct 21;15:1475146. doi: 10.3389/fimmu.2024.1475146. eCollection 2024. Front Immunol. 2024. PMID: 39497830 Free PMC article.
Compartmentalized cytotoxic immune response leads to distinct pathogenic roles of natural killer and senescent CD8+ T cells in human cutaneous leishmaniasis.
Covre LP, Devine OP, Garcia de Moura R, Vukmanovic-Stejic M, Dietze R, Ribeiro-Rodrigues R, Guedes HLM, Lubiana Zanotti R, Falqueto A, Akbar AN, Gomes DCO. Covre LP, et al. Among authors: gomes dco. Immunology. 2020 Apr;159(4):429-440. doi: 10.1111/imm.13173. Epub 2020 Jan 26. Immunology. 2020. PMID: 31925782 Free PMC article.
PD-1 Blockade Modulates Functional Activities of Exhausted-Like T Cell in Patients With Cutaneous Leishmaniasis.
Garcia de Moura R, Covre LP, Fantecelle CH, Gajardo VAT, Cunha CB, Stringari LL, Belew AT, Daniel CB, Zeidler SVV, Tadokoro CE, de Matos Guedes HL, Zanotti RL, Mosser D, Falqueto A, Akbar AN, Gomes DCO. Garcia de Moura R, et al. Among authors: gomes dco. Front Immunol. 2021 Mar 9;12:632667. doi: 10.3389/fimmu.2021.632667. eCollection 2021. Front Immunol. 2021. PMID: 33767700 Free PMC article.
Leishmania Parasites Drive PD-L1 Expression in Mice and Human Neutrophils With Suppressor Capacity.
da Fonseca-Martins AM, de Souza Lima-Gomes P, Antunes MM, de Moura RG, Covre LP, Calôba C, Rocha VG, Pereira RM, Menezes GB, Gomes DCO, Saraiva EM, de Matos Guedes HL. da Fonseca-Martins AM, et al. Among authors: gomes dco. Front Immunol. 2021 Jun 15;12:598943. doi: 10.3389/fimmu.2021.598943. eCollection 2021. Front Immunol. 2021. PMID: 34211455 Free PMC article.
Senescent T cells: Beneficial and detrimental roles.
Laphanuwat P, Gomes DCO, Akbar AN. Laphanuwat P, et al. Among authors: gomes dco. Immunol Rev. 2023 Jul;316(1):160-175. doi: 10.1111/imr.13206. Epub 2023 Apr 25. Immunol Rev. 2023. PMID: 37098109 Free PMC article. Review.
NKG2C+CD57+ natural killer cells with senescent features are induced during cutaneous leishmaniasis and accumulate in patients with lesional healing impairment.
Covre LP, Fantecelle CH, Queiroz AM, Fardin JM, Miranda PH, Henson S, Fonseca-Martins AMD, de Matos Guedes HL, Mosser D, Falqueto A, Akbar A, Gomes DCO. Covre LP, et al. Among authors: gomes dco. Clin Exp Immunol. 2024 Aug 9;217(3):279-290. doi: 10.1093/cei/uxae040. Clin Exp Immunol. 2024. PMID: 38700066
Senescence-related genes are associated with the immunopathology signature of American Tegumentary Leishmaniasis lesions and may predict progression to mucosal leishmaniasis.
Fantecelle CH, Polaco Covre L, Lopes PO, Sarmento IV, Decote-Ricardo D, Geraldo Freire de Lima C, de Matos Guedes HL, Pimentel MIF, Conceição-Silva F, Maretti-Mira AC, Borges VM, Pedreira de Carvalho L, de Carvalho EM, Mosser D, Falqueto A, Akbar AN, Gomes DCO. Fantecelle CH, et al. Among authors: gomes dco. Clin Exp Immunol. 2024 Oct 21:uxae088. doi: 10.1093/cei/uxae088. Online ahead of print. Clin Exp Immunol. 2024. PMID: 39428748
Pam3CSK4 adjuvant given intranasally boosts anti-Leishmania immunogenicity but not protective immune responses conferred by LaAg vaccine against visceral leishmaniasis.
Salgado CL, Dias EL, Stringari LL, Covre LP, Dietze R, Lima Pereira FE, de Matos Guedes HL, Rossi-Bergmann B, Gomes DCO. Salgado CL, et al. Among authors: gomes dco. Microbes Infect. 2019 Aug-Sep;21(7):328-335. doi: 10.1016/j.micinf.2019.02.005. Epub 2019 Feb 25. Microbes Infect. 2019. PMID: 30817996 Free article.
Characterization of Sv129 Mice as a Susceptible Model to Leishmania amazonensis.
Dos-Santos JS, Firmino-Cruz L, Ramos TD, da Fonseca-Martins AM, Oliveira-Maciel D, De-Medeiros JVR, Chaves SP, Gomes DCO, de Matos Guedes HL. Dos-Santos JS, et al. Among authors: gomes dco. Front Med (Lausanne). 2019 May 29;6:100. doi: 10.3389/fmed.2019.00100. eCollection 2019. Front Med (Lausanne). 2019. PMID: 31192210 Free PMC article.
41 results