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Page 1
CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson's Disease Associated Protein.
Li F, Ackloo S, Arrowsmith CH, Ban F, Barden CJ, Beck H, Beránek J, Berenger F, Bolotokova A, Bret G, Breznik M, Carosati E, Chau I, Chen Y, Cherkasov A, Corte DD, Denzinger K, Dong A, Draga S, Dunn I, Edfeldt K, Edwards A, Eguida M, Eisenhuth P, Friedrich L, Fuerll A, Gardiner SS, Gentile F, Ghiabi P, Gibson E, Glavatskikh M, Gorgulla C, Guenther J, Gunnarsson A, Gusev F, Gutkin E, Halabelian L, Harding RJ, Hillisch A, Hoffer L, Hogner A, Houliston S, Irwin JJ, Isayev O, Ivanova A, Jacquemard C, Jarrett AJ, Jensen JH, Kireev D, Kleber J, Koby SB, Koes D, Kumar A, Kurnikova MG, Kutlushina A, Lessel U, Liessmann F, Liu S, Lu W, Meiler J, Mettu A, Minibaeva G, Moretti R, Morris CJ, Narangoda C, Noonan T, Obendorf L, Pach S, Pandit A, Perveen S, Poda G, Polishchuk P, Puls K, Pütter V, Rognan D, Roskams-Edris D, Schindler C, Sindt F, Spiwok V, Steinmann C, Stevens RL, Talagayev V, Tingey D, Vu O, Walters WP, Wang X, Wang Z, Wolber G, Wolf CA, Wortmann L, Zeng H, Zepeda CA, Zhang KYJ, Zhang J, Zheng S, Schapira M. Li F, et al. Among authors: barden cj. J Chem Inf Model. 2024 Nov 25;64(22):8521-8536. doi: 10.1021/acs.jcim.4c01267. Epub 2024 Nov 5. J Chem Inf Model. 2024. PMID: 39499532
Computer-aided drug design to generate a unique antibiotic family.
Barden CJ, Wu F, Fernandez-Murray JP, Lu E, Sun S, Taylor MM, Rushton AL, Williams J, Tavasoli M, Meek A, Reddy AS, Doyle LM, Sagamanova I, Sivamuthuraman K, Boudreau RTM, Byers DM, Weaver DF, McMaster CR. Barden CJ, et al. Nat Commun. 2024 Sep 27;15(1):8317. doi: 10.1038/s41467-024-52797-2. Nat Commun. 2024. PMID: 39333560 Free PMC article.
Nebulized Furosemide for Pulmonary Inflammation in Intubated Patients With COVID-19: A Phase 2 Randomized Controlled Double-Blind Study.
Muscedere J, Maslove DM, Barden CJ, Weaver DF, Boyd JG, Sibley S, Boyd T, Rewa O, Albert M, Roussos M, Norman PA, Day AG. Muscedere J, et al. Among authors: barden cj. Crit Care Explor. 2024 Feb 2;6(2):e1045. doi: 10.1097/CCE.0000000000001045. eCollection 2024 Feb. Crit Care Explor. 2024. PMID: 38511126 Free PMC article.
Alzheimer's disease as an autoimmune disorder of innate immunity endogenously modulated by tryptophan metabolites.
Meier-Stephenson FS, Meier-Stephenson VC, Carter MD, Meek AR, Wang Y, Pan L, Chen Q, Jacobo S, Wu F, Lu E, Simms GA, Fisher L, McGrath AJ, Fermo V, Barden CJ, Clair HDS, Galloway TN, Yadav A, Campágna-Slater V, Hadden M, Reed M, Taylor M, Kelly B, Diez-Cecilia E, Kolaj I, Santos C, Liyanage I, Sweeting B, Stafford P, Boudreau R, Reid GA, Noyce RS, Stevens L, Staniszewski A, Zhang H, Murty MRVS, Lemaire P, Chardonnet S, Richardson CD, Gabelica V, DePauw E, Brown R, Darvesh S, Arancio O, Weaver DF. Meier-Stephenson FS, et al. Among authors: barden cj. Alzheimers Dement (N Y). 2022 Apr 6;8(1):e12283. doi: 10.1002/trc2.12283. eCollection 2022. Alzheimers Dement (N Y). 2022. PMID: 35415204 Free PMC article.
Furazans in Medicinal Chemistry.
Mancini RS, Barden CJ, Weaver DF, Reed MA. Mancini RS, et al. Among authors: barden cj. J Med Chem. 2021 Feb 25;64(4):1786-1815. doi: 10.1021/acs.jmedchem.0c01901. Epub 2021 Feb 11. J Med Chem. 2021. PMID: 33569941 Review.
The Brain Exposure Efficiency (BEE) Score.
Gupta M, Bogdanowicz T, Reed MA, Barden CJ, Weaver DF. Gupta M, et al. Among authors: barden cj. ACS Chem Neurosci. 2020 Jan 15;11(2):205-224. doi: 10.1021/acschemneuro.9b00650. Epub 2019 Dec 27. ACS Chem Neurosci. 2020. PMID: 31815431
The Blood-Brain Barrier (BBB) Score.
Gupta M, Lee HJ, Barden CJ, Weaver DF. Gupta M, et al. Among authors: barden cj. J Med Chem. 2019 Nov 14;62(21):9824-9836. doi: 10.1021/acs.jmedchem.9b01220. Epub 2019 Oct 25. J Med Chem. 2019. PMID: 31603678
12 results