Dutta AK - Search Results

1

Novel Piperazine Based Compounds Target Alzheimer's Disease Relevant Amyloid β42 and Tau Derived Peptide AcPHF6, and the Lead Molecule Increases Viability in the Flies Expressing Human Tau Protein.

Armstrong C, Luo D, Gretzinger A, Pandey D, Lipchik A, Todi SV, Dutta AK. Armstrong C, et al. Among authors: dutta ak. ACS Chem Neurosci. 2024 Nov 6;15(21):3901-3914. doi: 10.1021/acschemneuro.4c00220. Epub 2024 Oct 10. ACS Chem Neurosci. 2024. PMID: 39501783

2

Targeting alpha synuclein and amyloid beta by a multifunctional, brain-penetrant dopamine D2/D3 agonist D-520: Potential therapeutic application in Parkinson's disease with dementia.

Yedlapudi D, Xu L, Luo D, Marsh GB, Todi SV, Dutta AK. Yedlapudi D, et al. Among authors: dutta ak. Sci Rep. 2019 Dec 23;9(1):19648. doi: 10.1038/s41598-019-55830-3. Sci Rep. 2019. PMID: 31873106 Free PMC article.

3

D-685 Reverses Motor Deficits and Reduces Accumulation of Human α-Synuclein Protein in Two Different Parkinson's Disease Animal Models.

Dutta AK, Armstrong C, Luo D, Das B, Spencer B, Rissman RA. Dutta AK, et al. ACS Chem Neurosci. 2023 Mar 1;14(5):885-896. doi: 10.1021/acschemneuro.2c00655. Epub 2023 Feb 7. ACS Chem Neurosci. 2023. PMID: 36749600

4

Inhibition of alpha-synuclein aggregation by multifunctional dopamine agonists assessed by a novel in vitro assay and an in vivo Drosophila synucleinopathy model.

Yedlapudi D, Joshi GS, Luo D, Todi SV, Dutta AK. Yedlapudi D, et al. Among authors: dutta ak. Sci Rep. 2016 Dec 5;6:38510. doi: 10.1038/srep38510. Sci Rep. 2016. PMID: 27917933 Free PMC article.

5

A novel iron (II) preferring dopamine agonist chelator D-607 significantly suppresses α-syn- and MPTP-induced toxicities in vivo.

Das B, Rajagopalan S, Joshi GS, Xu L, Luo D, Andersen JK, Todi SV, Dutta AK. Das B, et al. Among authors: dutta ak. Neuropharmacology. 2017 Sep 1;123:88-99. doi: 10.1016/j.neuropharm.2017.05.019. Epub 2017 May 19. Neuropharmacology. 2017. PMID: 28533164 Free PMC article.

6

The multifunctional dopamine D₂/D₃ receptor agonists also possess inhibitory activity against the full-length tau441 protein aggregation.

Ziu I, Rettig I, Luo D, Dutta A, McCormick TM, Wu C, Martic S. Ziu I, et al. Bioorg Med Chem. 2020 Sep 15;28(18):115667. doi: 10.1016/j.bmc.2020.115667. Epub 2020 Jul 28. Bioorg Med Chem. 2020. PMID: 32828429 Free PMC article.

7

Development of a Highly Potent D2/D3 Agonist and a Partial Agonist from Structure-Activity Relationship Study of N(6)-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N(6)-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Analogues: Implication in the Treatment of Parkinson's Disease.

Das B, Vedachalam S, Luo D, Antonio T, Reith ME, Dutta AK. Das B, et al. Among authors: dutta ak. J Med Chem. 2015 Dec 10;58(23):9179-95. doi: 10.1021/acs.jmedchem.5b01031. Epub 2015 Nov 30. J Med Chem. 2015. PMID: 26555041 Free PMC article.

8

Novel multifunctional dopamine D₂/D₃ receptors agonists with potential neuroprotection and anti-alpha synuclein protein aggregation properties.

Luo D, Sharma H, Yedlapudi D, Antonio T, Reith MEA, Dutta AK. Luo D, et al. Among authors: dutta ak. Bioorg Med Chem. 2016 Nov 1;24(21):5088-5102. doi: 10.1016/j.bmc.2016.08.021. Epub 2016 Aug 20. Bioorg Med Chem. 2016. PMID: 27591013

9

A Novel Iron(II) Preferring Dopamine Agonist Chelator as Potential Symptomatic and Neuroprotective Therapeutic Agent for Parkinson's Disease.

Das B, Kandegedara A, Xu L, Antonio T, Stemmler T, Reith MEA, Dutta AK. Das B, et al. Among authors: dutta ak. ACS Chem Neurosci. 2017 Apr 19;8(4):723-730. doi: 10.1021/acschemneuro.6b00356. Epub 2017 Jan 27. ACS Chem Neurosci. 2017. PMID: 28106982

10

Design, Synthesis, and Pharmacological Characterization of Carbazole Based Dopamine Agonists as Potential Symptomatic and Neuroprotective Therapeutic Agents for Parkinson's Disease.

Elmabruk A, Das B, Yedlapudi D, Xu L, Antonio T, Reith MEA, Dutta AK. Elmabruk A, et al. Among authors: dutta ak. ACS Chem Neurosci. 2019 Jan 16;10(1):396-411. doi: 10.1021/acschemneuro.8b00291. Epub 2018 Oct 24. ACS Chem Neurosci. 2019. PMID: 30301349

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