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Novel Piperazine Based Compounds Target Alzheimer's Disease Relevant Amyloid β42 and Tau Derived Peptide AcPHF6, and the Lead Molecule Increases Viability in the Flies Expressing Human Tau Protein.
Armstrong C, Luo D, Gretzinger A, Pandey D, Lipchik A, Todi SV, Dutta AK. Armstrong C, et al. Among authors: lipchik a. ACS Chem Neurosci. 2024 Nov 6;15(21):3901-3914. doi: 10.1021/acschemneuro.4c00220. Epub 2024 Oct 10. ACS Chem Neurosci. 2024. PMID: 39501783
Acetyl-Click Screening Platform Identifies Small-Molecule Inhibitors of Histone Acetyltransferase 1 (HAT1).
Gaddameedi JD, Chou T, Geller BS, Rangarajan A, Swaminathan TA, Dixon D, Long K, Golder CJ, Vuong VA, Banuelos S, Greenhouse R, Snyder MP, Lipchik AM, Gruber JJ. Gaddameedi JD, et al. Among authors: lipchik am. J Med Chem. 2023 Apr 27;66(8):5774-5801. doi: 10.1021/acs.jmedchem.3c00039. Epub 2023 Apr 7. J Med Chem. 2023. PMID: 37027002 Free PMC article.
Chromatin Remodeling in Response to BRCA2-Crisis.
Gruber JJ, Chen J, Geller B, Jäger N, Lipchik AM, Wang G, Kurian AW, Ford JM, Snyder MP. Gruber JJ, et al. Among authors: lipchik am. Cell Rep. 2019 Aug 20;28(8):2182-2193.e6. doi: 10.1016/j.celrep.2019.07.057. Cell Rep. 2019. PMID: 31433991 Free PMC article.
HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding.
Gruber JJ, Geller B, Lipchik AM, Chen J, Salahudeen AA, Ram AN, Ford JM, Kuo CJ, Snyder MP. Gruber JJ, et al. Among authors: lipchik am. Mol Cell. 2019 Aug 22;75(4):711-724.e5. doi: 10.1016/j.molcel.2019.05.034. Epub 2019 Jul 2. Mol Cell. 2019. PMID: 31278053 Free PMC article.
16 results