Luo D - Search Results

1

Novel Piperazine Based Compounds Target Alzheimer's Disease Relevant Amyloid β42 and Tau Derived Peptide AcPHF6, and the Lead Molecule Increases Viability in the Flies Expressing Human Tau Protein.

Armstrong C, Luo D, Gretzinger A, Pandey D, Lipchik A, Todi SV, Dutta AK. Armstrong C, et al. Among authors: luo d. ACS Chem Neurosci. 2024 Nov 6;15(21):3901-3914. doi: 10.1021/acschemneuro.4c00220. Epub 2024 Oct 10. ACS Chem Neurosci. 2024. PMID: 39501783

2

Development of a Highly Potent D2/D3 Agonist and a Partial Agonist from Structure-Activity Relationship Study of N(6)-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N(6)-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Analogues: Implication in the Treatment of Parkinson's Disease.

Das B, Vedachalam S, Luo D, Antonio T, Reith ME, Dutta AK. Das B, et al. Among authors: luo d. J Med Chem. 2015 Dec 10;58(23):9179-95. doi: 10.1021/acs.jmedchem.5b01031. Epub 2015 Nov 30. J Med Chem. 2015. PMID: 26555041 Free PMC article.

3

Novel multifunctional dopamine D₂/D₃ receptors agonists with potential neuroprotection and anti-alpha synuclein protein aggregation properties.

Luo D, Sharma H, Yedlapudi D, Antonio T, Reith MEA, Dutta AK. Luo D, et al. Bioorg Med Chem. 2016 Nov 1;24(21):5088-5102. doi: 10.1016/j.bmc.2016.08.021. Epub 2016 Aug 20. Bioorg Med Chem. 2016. PMID: 27591013

4

Inhibition of alpha-synuclein aggregation by multifunctional dopamine agonists assessed by a novel in vitro assay and an in vivo Drosophila synucleinopathy model.

Yedlapudi D, Joshi GS, Luo D, Todi SV, Dutta AK. Yedlapudi D, et al. Among authors: luo d. Sci Rep. 2016 Dec 5;6:38510. doi: 10.1038/srep38510. Sci Rep. 2016. PMID: 27917933 Free PMC article.

5

A novel iron (II) preferring dopamine agonist chelator D-607 significantly suppresses α-syn- and MPTP-induced toxicities in vivo.

Das B, Rajagopalan S, Joshi GS, Xu L, Luo D, Andersen JK, Todi SV, Dutta AK. Das B, et al. Among authors: luo d. Neuropharmacology. 2017 Sep 1;123:88-99. doi: 10.1016/j.neuropharm.2017.05.019. Epub 2017 May 19. Neuropharmacology. 2017. PMID: 28533164 Free PMC article.

6

Targeting alpha synuclein and amyloid beta by a multifunctional, brain-penetrant dopamine D2/D3 agonist D-520: Potential therapeutic application in Parkinson's disease with dementia.

Yedlapudi D, Xu L, Luo D, Marsh GB, Todi SV, Dutta AK. Yedlapudi D, et al. Among authors: luo d. Sci Rep. 2019 Dec 23;9(1):19648. doi: 10.1038/s41598-019-55830-3. Sci Rep. 2019. PMID: 31873106 Free PMC article.

7

The multifunctional dopamine D₂/D₃ receptor agonists also possess inhibitory activity against the full-length tau441 protein aggregation.

Ziu I, Rettig I, Luo D, Dutta A, McCormick TM, Wu C, Martic S. Ziu I, et al. Among authors: luo d. Bioorg Med Chem. 2020 Sep 15;28(18):115667. doi: 10.1016/j.bmc.2020.115667. Epub 2020 Jul 28. Bioorg Med Chem. 2020. PMID: 32828429 Free PMC article.

8

D-685 Reverses Motor Deficits and Reduces Accumulation of Human α-Synuclein Protein in Two Different Parkinson's Disease Animal Models.

Dutta AK, Armstrong C, Luo D, Das B, Spencer B, Rissman RA. Dutta AK, et al. Among authors: luo d. ACS Chem Neurosci. 2023 Mar 1;14(5):885-896. doi: 10.1021/acschemneuro.2c00655. Epub 2023 Feb 7. ACS Chem Neurosci. 2023. PMID: 36749600

9

Searching for Synthetic Opioid Rescue Agents: Identification of a Potent Opioid Agonist with Reduced Respiratory Depression.

Vu LY, Luo D, Johnson K, Denehy ED, Songrady JC, Martin J, Trivedi R, Alsum AR, Shaykin JD, Chaudhary CL, Woloshin EJ, Kornberger L, Bhuiyan N, Parkin S, Jiang Q, Che T, Alilain W, Turner JR, Bardo MT, Prisinzano TE. Vu LY, et al. Among authors: luo d. J Med Chem. 2024 Jun 13;67(11):9173-9193. doi: 10.1021/acs.jmedchem.4c00333. Epub 2024 May 29. J Med Chem. 2024. PMID: 38810170

10

Discovery of Potent Kappa Opioid Receptor Agonists Derived from Akuammicine.

Hennessy MR, Creed SM, Gutridge AM, Rusali LE, Luo D, Sepehri B, Rhoda ES, Villegas JA, van Rijn RM, Riley AP. Hennessy MR, et al. Among authors: luo d. J Med Chem. 2024 Dec 12;67(23):20842-20857. doi: 10.1021/acs.jmedchem.4c00736. Epub 2024 Nov 20. J Med Chem. 2024. PMID: 39565354

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