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Multi-omics reveal immune microenvironment alterations in multiple myeloma and its precursor stages.
Cheng Y, Sun F, Alapat DV, Wanchai V, Mery D, Siegel ER, Xu H, Johnson S, Guo W, Bailey C, Ashby C, Bauer MA, Hadidi SA, Schinke C, Thanendrarajan S, Zangari M, van Rhee F, Tricot G, Shaughnessy JD Jr, Zhan F. Cheng Y, et al. Among authors: xu h. Blood Cancer J. 2024 Nov 6;14(1):194. doi: 10.1038/s41408-024-01172-x. Blood Cancer J. 2024. PMID: 39505839 Free PMC article.
A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1.
Shaughnessy JD Jr, Zhan F, Burington BE, Huang Y, Colla S, Hanamura I, Stewart JP, Kordsmeier B, Randolph C, Williams DR, Xiao Y, Xu H, Epstein J, Anaissie E, Krishna SG, Cottler-Fox M, Hollmig K, Mohiuddin A, Pineda-Roman M, Tricot G, van Rhee F, Sawyer J, Alsayed Y, Walker R, Zangari M, Crowley J, Barlogie B. Shaughnessy JD Jr, et al. Among authors: xu h. Blood. 2007 Mar 15;109(6):2276-84. doi: 10.1182/blood-2006-07-038430. Epub 2006 Nov 14. Blood. 2007. PMID: 17105813 Free article.
A gene signature can predict risk of MGUS progressing to multiple myeloma.
Sun F, Cheng Y, Ying J, Mery D, Al Hadidi S, Wanchai V, Siegel ER, Xu H, Gai D, Ashby TC, Bailey C, Chen JR, Schinke C, Thanendrarajan S, Zangari M, Janz S, Barlogie B, Van Rhee F, Tricot G, Shaughnessy JD Jr, Zhan F. Sun F, et al. Among authors: xu h. J Hematol Oncol. 2023 Jun 29;16(1):70. doi: 10.1186/s13045-023-01472-y. J Hematol Oncol. 2023. PMID: 37386588 Free PMC article.
High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma.
Cheng Y, Sun F, Alapat DV, Wanchai V, Mery D, Guo W, Cao H, Zhu Y, Ashby C, Bauer MA, Nookaew I, Siegel ER, Ying J, Chen JR, Gai D, Peng B, Xu H, Bailey C, Al Hadidi S, Schinke C, Thanendrarajan S, Zangari M, Chesi M, Bergsagel PL, van Rhee F, Janz S, Tricot G, Shaughnessy JD Jr, Zhan F. Cheng Y, et al. Among authors: xu h. Cell Rep Med. 2023 Oct 17;4(10):101214. doi: 10.1016/j.xcrm.2023.101214. Epub 2023 Oct 3. Cell Rep Med. 2023. PMID: 37794587 Free PMC article.
Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth.
Sun F, Cheng Y, Wanchai V, Guo W, Mery D, Xu H, Gai D, Siegel E, Bailey C, Ashby C, Al Hadidi S, Schinke C, Thanendrarajan S, Ma Y, Yi Q, Orlowski RZ, Zangari M, van Rhee F, Janz S, Bishop G, Tricot G, Shaughnessy JD Jr, Zhan F. Sun F, et al. Among authors: xu h. Nat Commun. 2024 Jan 19;15(1):615. doi: 10.1038/s41467-024-44873-4. Nat Commun. 2024. PMID: 38242888 Free PMC article.
CST6 suppresses osteolytic bone disease in multiple myeloma by blocking osteoclast differentiation.
Gai D, Chen JR, Stewart JP, Nookaew I, Habelhah H, Ashby C, Sun F, Cheng Y, Li C, Xu H, Peng B, Garg TK, Schinke C, Thanendrarajan S, Zangari M, Chen F, Barlogie B, van Rhee F, Tricot G, Shaughnessy JD Jr, Zhan F. Gai D, et al. Among authors: xu h. J Clin Invest. 2022 Sep 15;132(18):e159527. doi: 10.1172/JCI159527. J Clin Invest. 2022. PMID: 35881476 Free PMC article.
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