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FLT3 signaling inhibition abrogates opioid tolerance and hyperalgesia while preserving analgesia.
Jouvenel A, Tassou A, Thouaye M, Ruel J, Antri M, Leyris JP, Giraudin A, Mallié S, Sar C, Diouloufet L, Sonrier C, Daubeuf F, Bertin J, Alves S, Ventéo S, Frossard N, Carroll P, Mechaly I, Rognan D, Sokoloff P, Dallel R, Delmas P, Valmier J, Rivat C. Jouvenel A, et al. Among authors: sokoloff p. Nat Commun. 2024 Nov 7;15(1):9633. doi: 10.1038/s41467-024-54054-y. Nat Commun. 2024. PMID: 39511220 Free PMC article.
Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice.
Rivat C, Sar C, Mechaly I, Leyris JP, Diouloufet L, Sonrier C, Philipson Y, Lucas O, Mallié S, Jouvenel A, Tassou A, Haton H, Venteo S, Pin JP, Trinquet E, Charrier-Savournin F, Mezghrani A, Joly W, Mion J, Schmitt M, Pattyn A, Marmigère F, Sokoloff P, Carroll P, Rognan D, Valmier J. Rivat C, et al. Among authors: sokoloff p. Nat Commun. 2018 Mar 12;9(1):1042. doi: 10.1038/s41467-018-03496-2. Nat Commun. 2018. PMID: 29531216 Free PMC article.
High-Throughput Screening for Extracellular Inhibitors of the FLT3 Receptor Tyrosine Kinase Reveals Chemically Diverse and Druggable Negative Allosteric Modulators.
Hany R, Leyris JP, Bret G, Mallié S, Sar C, Thouaye M, Hamze A, Provot O, Sokoloff P, Valmier J, Villa P, Rognan D. Hany R, et al. Among authors: sokoloff p. ACS Chem Biol. 2022 Mar 18;17(3):709-722. doi: 10.1021/acschembio.2c00048. Epub 2022 Feb 28. ACS Chem Biol. 2022. PMID: 35227060 Free article.
158 results