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Page 1
Therapy-relevant MDM2 amplification in cholangiocarcinomas in Caucasian patients.
Lyu SI, Plum PS, Fretter C, Simon AG, Bedau T, Knipper K, Thomas MN, Stippel D, Wagner BJ, Bruns C, Waldschmidt D, Büttner R, Drebber U, Quaas A. Lyu SI, et al. Among authors: bedau t. Ther Adv Med Oncol. 2024 Nov 9;16:17588359241288123. doi: 10.1177/17588359241288123. eCollection 2024. Ther Adv Med Oncol. 2024. PMID: 39525665 Free PMC article.
Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro.
Bedau T, Schumacher N, Peters F, Prox J, Arnold P, Koudelka T, Helm O, Schmidt F, Rabe B, Jentzsch M, Rosenstiel P, Sebens S, Tholey A, Rose-John S, Becker-Pauly C. Bedau T, et al. Oncotarget. 2017 Jul 4;8(33):54873-54888. doi: 10.18632/oncotarget.18966. eCollection 2017 Aug 15. Oncotarget. 2017. PMID: 28903388 Free PMC article.
Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin β and promotes transendothelial cell migration.
Bedau T, Peters F, Prox J, Arnold P, Schmidt F, Finkernagel M, Köllmann S, Wichert R, Otte A, Ohler A, Stirnberg M, Lucius R, Koudelka T, Tholey A, Biasin V, Pietrzik CU, Kwapiszewska G, Becker-Pauly C. Bedau T, et al. FASEB J. 2017 Mar;31(3):1226-1237. doi: 10.1096/fj.201601113R. Epub 2016 Dec 21. FASEB J. 2017. PMID: 28003343