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Discovery of novel thiosemicarbazone-acridine targeting butyrylcholinesterase with antioxidant, metal complexing and neuroprotector abilities as potential treatment of Alzheimer's disease: In vitro, in vivo, and in silico studies.
Silva Sousa GL, Nadur NF, de Almeida Peixoto Ferreira L, da Silva Honório T, Simon A, Cabral LM, Móra Santos ML, Andrade B, de Lima EV, Clarke JR, Castro RN, Olímpio de Moura R, Kümmerle AE. Silva Sousa GL, et al. Among authors: clarke jr. Eur J Med Chem. 2024 Nov 7;281:117030. doi: 10.1016/j.ejmech.2024.117030. Online ahead of print. Eur J Med Chem. 2024. PMID: 39531933
Abatacept inhibits Th17 differentiation and mitigates α-synuclein-induced dopaminergic dysfunction in mice.
Clarke JR, Bacelar TS, Fernandes GG, Silva RCD, Antonio LS, Queiroz M, de Souza RV, Valadão LF, Ribeiro GS, De Lima EV, Colodeti LC, Mangeth LC, Wiecikowski A, da Silva TN, Paula-Neto HA, da Costa R, Cordeiro Y, Passos GF, Figueiredo CP. Clarke JR, et al. Mol Psychiatry. 2024 Aug 16. doi: 10.1038/s41380-024-02618-1. Online ahead of print. Mol Psychiatry. 2024. PMID: 39152331
Immunosuppression-induced Zika virus reactivation causes brain inflammation and behavioral deficits in mice.
Nogueira CO, Lopes da Silva MO, de Lima EV, Christoff RR, Gavino-Leopoldino D, Lemos FS, da Silva NE, Da Poian AT, Assunção-Miranda I, Figueiredo CP, Clarke JR. Nogueira CO, et al. Among authors: clarke jr. iScience. 2024 Jun 5;27(7):110178. doi: 10.1016/j.isci.2024.110178. eCollection 2024 Jul 19. iScience. 2024. PMID: 38993676 Free PMC article.
TNF-α blockage prevents late neurological consequences of Zika virus infection in mice.
Christoff RR, Liesner IL, Gavino-Leopoldino D, Andrade B, Oliveira de Campos B, Salgado I, Simões-Lemos F, Da Poian AT, Assunção-Miranda I, Figueiredo CP, Clarke JR. Christoff RR, et al. Among authors: clarke jr. Behav Brain Res. 2024 Aug 5;471:115114. doi: 10.1016/j.bbr.2024.115114. Epub 2024 Jun 13. Behav Brain Res. 2024. PMID: 38878972
ATP-P2X7 signaling mediates brain pathology while contributing to viral control in perinatal Zika virus infection.
Leite-Aguiar R, Cristina-Rodrigues F, Ciarlini-Magalhães R, Dantas DP, Alves VS, Gavino-Leopoldino D, Neris RLS, Schmitz F, Silveira JS, Kurtenbach E, Wyse ATS, Clarke JR, Figueiredo CP, Assunção-Miranda I, Pimentel-Coelho PM, Coutinho-Silva R, Savio LEB. Leite-Aguiar R, et al. Among authors: clarke jr. Brain Behav Immun. 2024 May;118:318-333. doi: 10.1016/j.bbi.2024.02.035. Epub 2024 Mar 7. Brain Behav Immun. 2024. PMID: 38460804
Zika virus infection impairs synaptogenesis, induces neuroinflammation, and could be an environmental risk factor for autism spectrum disorder outcome.
Ohki CMY, Benazzato C, van der Linden V, França JV, Toledo CM, Machado RRG, Araujo DB, Oliveira DBL, Neris RS, Assunção-Miranda I, de Oliveira Souza IN, Nogueira CO, Leite PEC, van der Linden H, Figueiredo CP, Durigon EL, Clarke JR, Russo FB, Beltrão-Braga PCB. Ohki CMY, et al. Among authors: clarke jr. Biochim Biophys Acta Mol Basis Dis. 2024 Jun;1870(5):167097. doi: 10.1016/j.bbadis.2024.167097. Epub 2024 Feb 24. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 38408544
335 results