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Page 1
Discovery of novel thiosemicarbazone-acridine targeting butyrylcholinesterase with antioxidant, metal complexing and neuroprotector abilities as potential treatment of Alzheimer's disease: In vitro, in vivo, and in silico studies.
Silva Sousa GL, Nadur NF, de Almeida Peixoto Ferreira L, da Silva Honório T, Simon A, Cabral LM, Móra Santos ML, Andrade B, de Lima EV, Clarke JR, Castro RN, Olímpio de Moura R, Kümmerle AE. Silva Sousa GL, et al. Among authors: de lima ev. Eur J Med Chem. 2024 Nov 7;281:117030. doi: 10.1016/j.ejmech.2024.117030. Online ahead of print. Eur J Med Chem. 2024. PMID: 39531933
Abatacept inhibits Th17 differentiation and mitigates α-synuclein-induced dopaminergic dysfunction in mice.
Clarke JR, Bacelar TS, Fernandes GG, Silva RCD, Antonio LS, Queiroz M, de Souza RV, Valadão LF, Ribeiro GS, De Lima EV, Colodeti LC, Mangeth LC, Wiecikowski A, da Silva TN, Paula-Neto HA, da Costa R, Cordeiro Y, Passos GF, Figueiredo CP. Clarke JR, et al. Among authors: de lima ev. Mol Psychiatry. 2024 Aug 16. doi: 10.1038/s41380-024-02618-1. Online ahead of print. Mol Psychiatry. 2024. PMID: 39152331
Immunosuppression-induced Zika virus reactivation causes brain inflammation and behavioral deficits in mice.
Nogueira CO, Lopes da Silva MO, de Lima EV, Christoff RR, Gavino-Leopoldino D, Lemos FS, da Silva NE, Da Poian AT, Assunção-Miranda I, Figueiredo CP, Clarke JR. Nogueira CO, et al. Among authors: de lima ev. iScience. 2024 Jun 5;27(7):110178. doi: 10.1016/j.isci.2024.110178. eCollection 2024 Jul 19. iScience. 2024. PMID: 38993676 Free PMC article.
SARS-CoV-2 Spike protein alters microglial purinergic signaling.
Alves VS, Santos SACS, Leite-Aguiar R, Paiva-Pereira E, Dos Reis RR, Calazans ML, Fernandes GG, Antônio LS, de Lima EV, Kurtenbach E, Silva JL, Fontes-Dantas FL, Passos GF, Figueiredo CP, Coutinho-Silva R, Savio LEB. Alves VS, et al. Among authors: de lima ev. Front Immunol. 2023 Apr 11;14:1158460. doi: 10.3389/fimmu.2023.1158460. eCollection 2023. Front Immunol. 2023. PMID: 37114062 Free PMC article.
SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice.
Fontes-Dantas FL, Fernandes GG, Gutman EG, De Lima EV, Antonio LS, Hammerle MB, Mota-Araujo HP, Colodeti LC, Araújo SMB, Froz GM, da Silva TN, Duarte LA, Salvio AL, Pires KL, Leon LAA, Vasconcelos CCF, Romão L, Savio LEB, Silva JL, da Costa R, Clarke JR, Da Poian AT, Alves-Leon SV, Passos GF, Figueiredo CP. Fontes-Dantas FL, et al. Among authors: de lima ev. Cell Rep. 2023 Mar 28;42(3):112189. doi: 10.1016/j.celrep.2023.112189. Epub 2023 Feb 17. Cell Rep. 2023. PMID: 36857178 Free PMC article.
Nanosystems for gene therapy targeting brain damage caused by viral infections.
da Silva TN, de Lima EV, Barradas TN, Testa CG, Picciani PHS, Figueiredo CP, do Carmo FA, Clarke JR. da Silva TN, et al. Among authors: de lima ev. Mater Today Bio. 2022 Dec 17;18:100525. doi: 10.1016/j.mtbio.2022.100525. eCollection 2023 Feb. Mater Today Bio. 2022. PMID: 36619201 Free PMC article. Review.
Prion protein complexed to a DNA aptamer induce behavioral and synapse dysfunction in mice.
P B Gomes M, de Lima EV, G Q Barros-Aragão F, Passos YM, Lemos FS, Zamberlan DC, Ribeiro G, Macedo B, C Ferreira N, Silva JL, Figueiredo CP, Clarke JR, Cordeiro Y. P B Gomes M, et al. Among authors: de lima ev. Behav Brain Res. 2022 Feb 15;419:113680. doi: 10.1016/j.bbr.2021.113680. Epub 2021 Nov 22. Behav Brain Res. 2022. PMID: 34822947
Antileishmanial Chemotherapy through Clemastine Fumarate Mediated Inhibition of the Leishmania Inositol Phosphorylceramide Synthase.
Mina JGM, Charlton RL, Alpizar-Sosa E, Escrivani DO, Brown C, Alqaisi A, Borsodi MPG, Figueiredo CP, de Lima EV, Dickie EA, Wei W, Coutinho-Silva R, Merritt A, Smith TK, Barrett MP, Rossi-Bergmann B, Denny PW, Steel PG. Mina JGM, et al. Among authors: de lima ev. ACS Infect Dis. 2021 Jan 8;7(1):47-63. doi: 10.1021/acsinfecdis.0c00546. Epub 2020 Dec 8. ACS Infect Dis. 2021. PMID: 33291887 Free PMC article.
16 results