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Discovery of highly potent and ALK2/ALK1 selective kinase inhibitors using DNA-encoded chemistry technology.
Jimmidi R, Monsivais D, Ta HM, Sharma KL, Bohren KM, Chamakuri S, Liao Z, Li F, Hakenjos JM, Li JY, Mishina Y, Pan H, Qin X, Robers MB, Sankaran B, Tan Z, Tang S, Vasquez YM, Wilkinson J, Young DW, Palmer SS, MacKenzie KR, Kim C, Matzuk MM. Jimmidi R, et al. Among authors: wilkinson j. Proc Natl Acad Sci U S A. 2024 Nov 19;121(47):e2413108121. doi: 10.1073/pnas.2413108121. Epub 2024 Nov 14. Proc Natl Acad Sci U S A. 2024. PMID: 39541346
Reversible male contraception by targeted inhibition of serine/threonine kinase 33.
Ku AF, Sharma KL, Ta HM, Sutton CM, Bohren KM, Wang Y, Chamakuri S, Chen R, Hakenjos JM, Jimmidi R, Kent K, Li F, Li JY, Ma L, Madasu C, Palaniappan M, Palmer SS, Qin X, Robers MB, Sankaran B, Tan Z, Vasquez YM, Wang J, Wilkinson J, Yu Z, Ye Q, Young DW, Teng M, Kim C, Matzuk MM. Ku AF, et al. Among authors: wilkinson j. Science. 2024 May 24;384(6698):885-890. doi: 10.1126/science.adl2688. Epub 2024 May 23. Science. 2024. PMID: 38781365
Protomer selectivity of type II RAF inhibitors within the RAS/RAF complex.
Vasta JD, Michaud A, Zimprich CA, Beck MT, Swiatnicki MR, Zegzouti H, Thomas MR, Wilkinson J, Crapster JA, Robers MB. Vasta JD, et al. Among authors: wilkinson j. Cell Chem Biol. 2023 Nov 16;30(11):1354-1365.e6. doi: 10.1016/j.chembiol.2023.07.019. Epub 2023 Aug 28. Cell Chem Biol. 2023. PMID: 37643616 Free article.
Quantifying CDK inhibitor selectivity in live cells.
Wells CI, Vasta JD, Corona CR, Wilkinson J, Zimprich CA, Ingold MR, Pickett JE, Drewry DH, Pugh KM, Schwinn MK, Hwang BB, Zegzouti H, Huber KVM, Cong M, Meisenheimer PL, Willson TM, Robers MB. Wells CI, et al. Among authors: wilkinson j. Nat Commun. 2020 Jun 2;11(1):2743. doi: 10.1038/s41467-020-16559-0. Nat Commun. 2020. PMID: 32488087 Free PMC article.
Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement.
Vasta JD, Corona CR, Wilkinson J, Zimprich CA, Hartnett JR, Ingold MR, Zimmerman K, Machleidt T, Kirkland TA, Huwiler KG, Ohana RF, Slater M, Otto P, Cong M, Wells CI, Berger BT, Hanke T, Glas C, Ding K, Drewry DH, Huber KVM, Willson TM, Knapp S, Müller S, Meisenheimer PL, Fan F, Wood KV, Robers MB. Vasta JD, et al. Among authors: wilkinson j. Cell Chem Biol. 2018 Feb 15;25(2):206-214.e11. doi: 10.1016/j.chembiol.2017.10.010. Epub 2017 Nov 22. Cell Chem Biol. 2018. PMID: 29174542 Free PMC article.
2,857 results