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A PSMA-targeted Tri-specific Killer Engager enhances NK cell cytotoxicity against prostate cancer.
Phung SK, Zorko NA, Soignier Y, Waller RL, Shackelford M, Walker JT, Nelson TD, Selleck C, Bendzick LE, Kotz LE, Kile QM, Bozicevich AJ, Miller SE, Khaw M, Shetty M, Hinderlie P, Ehrhardt M, Li Y, Luo X, Dehm SM, Antonarakis ES, Kennedy PR, Miller JS, Felices M. Phung SK, et al. Among authors: kennedy pr. Cancer Immunol Res. 2024 Nov 15. doi: 10.1158/2326-6066.CIR-24-0273. Online ahead of print. Cancer Immunol Res. 2024. PMID: 39545924
Metabolic programs drive function of therapeutic NK cells in hypoxic tumor environments.
Kennedy PR, Arvindam US, Phung SK, Ettestad B, Feng X, Li Y, Kile QM, Hinderlie P, Khaw M, Huang RS, Kaufman M, Puchalska P, Russell A, Butler J, Abbott L, McClure P, Luo X, Lu QT, Blazar BR, Crawford PA, Lim J, Miller JS, Felices M. Kennedy PR, et al. Sci Adv. 2024 Nov;10(44):eadn1849. doi: 10.1126/sciadv.adn1849. Epub 2024 Oct 30. Sci Adv. 2024. PMID: 39475618 Free PMC article.
A tri-specific killer engager against mesothelin targets NK cells towards lung cancer.
Kennedy PR, Vallera DA, Ettestad B, Hallstrom C, Kodal B, Todhunter DA, Bendzick L, Hinderlie P, Walker JT, Pulkrabek B, Pastan I, Kratzke RA, Fujioka N, Miller JS, Felices M. Kennedy PR, et al. Front Immunol. 2023 Feb 22;14:1060905. doi: 10.3389/fimmu.2023.1060905. eCollection 2023. Front Immunol. 2023. PMID: 36911670 Free PMC article.
Ablation of SYK Kinase from Expanded Primary Human NK Cells via CRISPR/Cas9 Enhances Cytotoxicity and Cytokine Production.
Dahlvang JD, Dick JK, Sangala JA, Kennedy PR, Pomeroy EJ, Snyder KM, Moushon JM, Thefaine CE, Wu J, Hamilton SE, Felices M, Miller JS, Walcheck B, Webber BR, Moriarity BS, Hart GT. Dahlvang JD, et al. Among authors: kennedy pr. J Immunol. 2023 Apr 15;210(8):1108-1122. doi: 10.4049/jimmunol.2200488. J Immunol. 2023. PMID: 36881874 Free PMC article.
Diversity of peripheral blood human NK cells identified by single-cell RNA sequencing.
Smith SL, Kennedy PR, Stacey KB, Worboys JD, Yarwood A, Seo S, Solloa EH, Mistretta B, Chatterjee SS, Gunaratne P, Allette K, Wang YC, Smith ML, Sebra R, Mace EM, Horowitz A, Thomson W, Martin P, Eyre S, Davis DM. Smith SL, et al. Among authors: kennedy pr. Blood Adv. 2020 Apr 14;4(7):1388-1406. doi: 10.1182/bloodadvances.2019000699. Blood Adv. 2020. PMID: 32271902 Free PMC article.
NK Cells Augment Oncolytic Adenovirus Cytotoxicity in Ovarian Cancer.
Leung EYL, Ennis DP, Kennedy PR, Hansell C, Dowson S, Farquharson M, Spiliopoulou P, Nautiyal J, McNamara S, Carlin LM, Fisher K, Davis DM, Graham G, McNeish IA. Leung EYL, et al. Among authors: kennedy pr. Mol Ther Oncolytics. 2020 Feb 15;16:289-301. doi: 10.1016/j.omto.2020.02.001. eCollection 2020 Mar 27. Mol Ther Oncolytics. 2020. PMID: 32195317 Free PMC article.
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