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Discovery of 1-(Phenylsulfonyl)-1,2,3,4-tetrahydroquinoline Derivative as Orally Bioavailable and Safe RORγt Inverse Agonists for Potential Treatment of Rheumatoid Arthritis.
Sun SL, Xu HJ, Jiang XL, Zhou J, Shi W, Wang XJ, Song W, Chang XY, Ma XQ, Zou XF, Wu SH, Yang J, Li QQ, Wang ZX, Cai J, Yu SP, Wang QX, Wei TH, Wu JZ, Tong ZJ, Zhou Y, Wang YB, Yu YC, Leng XJ, Ding N, Shi ZH, Dai WC, Xue X, Li NG, Wang XL. Sun SL, et al. Among authors: cai j. J Med Chem. 2024 Nov 15. doi: 10.1021/acs.jmedchem.4c01727. Online ahead of print. J Med Chem. 2024. PMID: 39546350
A novel mouse model recapitulating the MMR-defective SCLC subtype uncovers an actionable sensitivity to immune checkpoint blockade.
Ibruli O, Rose F, Beleggia F, Schmitt A, Cartolano M, Fernandez LT, Saggau J, Bonasera D, Kiljan M, Gozum G, Lichius L, Cai J, Niu LN, Caiaffa MI, Herter JM, Walczak H, Liccardi G, Grüll H, Büttner R, Bosco G, George J, Thomas RK, Bozek K, Reinhardt HC, Herter-Sprie GS. Ibruli O, et al. Among authors: cai j. J Cancer Res Clin Oncol. 2024 Nov 14;150(11):496. doi: 10.1007/s00432-024-05942-9. J Cancer Res Clin Oncol. 2024. PMID: 39542886
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