Schmidt J - Search Results

1

Synthesis and structure-affinity relationships of spirocyclic σ₁ receptor ligands with tetrahydropyran scaffold.

Winge T, Schepmann D, Schmidt J, Wünsch B. Winge T, et al. Among authors: schmidt j. Eur J Med Chem. 2025 Jan 5;281:117002. doi: 10.1016/j.ejmech.2024.117002. Epub 2024 Oct 26. Eur J Med Chem. 2025. PMID: 39547080 Free article.

2

Conformationally Restricted σ₁ Receptor Antagonists from (-)-Isopulegol.

Blicker L, González-Cano R, Laurini E, Nieto FR, Schmidt J, Schepmann D, Pricl S, Wünsch B. Blicker L, et al. Among authors: schmidt j. J Med Chem. 2023 Apr 13;66(7):4999-5020. doi: 10.1021/acs.jmedchem.2c02081. Epub 2023 Mar 22. J Med Chem. 2023. PMID: 36946301 Free article.

3

Indazole as a Phenol Bioisostere: Structure-Affinity Relationships of GluN2B-Selective NMDA Receptor Antagonists.

Lüken J, Goerges G, Ritter N, Disse P, Schreiber JA, Schmidt J, Frehland B, Schepmann D, Seebohm G, Wünsch B. Lüken J, et al. Among authors: schmidt j. J Med Chem. 2023 Aug 24;66(16):11573-11588. doi: 10.1021/acs.jmedchem.3c01161. Epub 2023 Aug 14. J Med Chem. 2023. PMID: 37580890

4

Diastereoselective synthesis and structure-affinity relationships of σ₁ receptor ligands with spirocyclic scaffold.

Winge T, Schepmann D, Schmidt J, Daniliuc C, Würthwein EU, Wünsch B. Winge T, et al. Among authors: schmidt j. Org Biomol Chem. 2023 Oct 4;21(38):7730-7752. doi: 10.1039/d3ob01169k. Org Biomol Chem. 2023. PMID: 37691601

5

Enantiomerically Pure Indazole Bioisosteres of Ifenprodil and Ro 25-6981 as Negative Allosteric Modulators of NMDA Receptors with the GluN2B Subunit.

Lüken J, Goerges G, Schreiber JA, Schmidt J, Frehland B, Schepmann D, Seebohm G, Wünsch B. Lüken J, et al. Among authors: schmidt j. J Med Chem. 2024 Nov 14;67(21):19678-19688. doi: 10.1021/acs.jmedchem.4c02035. Epub 2024 Oct 17. J Med Chem. 2024. PMID: 39418125

6

In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs.

Bechthold E, Grey L, Diamant E, Schmidt J, Steigerwald R, Zhao F, Hansen KB, Bunch L, Clausen RP, Wünsch B. Bechthold E, et al. Among authors: schmidt j. Biol Chem. 2022 Nov 25;404(4):255-265. doi: 10.1515/hsz-2022-0229. Print 2023 Mar 28. Biol Chem. 2022. PMID: 36427206 Free PMC article.

7

Negative allosteric modulators of NMDA receptors with GluN2B subunit: synthesis of β-aminoalcohols by epoxide opening and subsequent rearrangement.

Korff M, Lüken J, Schmidt J, Schepmann D, Goerges G, Ritter N, Disse P, Schreiber JA, Seebohm G, Wünsch B. Korff M, et al. Among authors: schmidt j. Org Biomol Chem. 2023 Sep 27;21(37):7616-7638. doi: 10.1039/d3ob01208e. Org Biomol Chem. 2023. PMID: 37682049

8

[¹⁸F]Fluspidine-A PET Tracer for Imaging of σ₁ Receptors in the Central Nervous System.

Ludwig FA, Laurini E, Schmidt J, Pricl S, Deuther-Conrad W, Wünsch B. Ludwig FA, et al. Among authors: schmidt j. Pharmaceuticals (Basel). 2024 Jan 28;17(2):166. doi: 10.3390/ph17020166. Pharmaceuticals (Basel). 2024. PMID: 38399380 Free PMC article. Review.

9

Scanning-tunneling-spectroscopy-directed design of tailored deep-blue emitters.

Sanning J, Ewen PR, Stegemann L, Schmidt J, Daniliuc CG, Koch T, Doltsinis NL, Wegner D, Strassert CA. Sanning J, et al. Among authors: schmidt j. Angew Chem Int Ed Engl. 2015 Jan 12;54(3):786-91. doi: 10.1002/anie.201407439. Epub 2014 Dec 17. Angew Chem Int Ed Engl. 2015. PMID: 25521940

10

Ubiquitin-mediated recruitment of the ATG9A-ATG2 lipid transfer complex drives clearance of phosphorylated p62 aggregates.

Broadbent DG, McEwan CM, Jayatunge D, Kaminsky EG, Tsang TM, Poole DM, Naylor BC, Price JC, Schmidt JC, Andersen JL. Broadbent DG, et al. Among authors: schmidt jc. Mol Biol Cell. 2024 Dec 24:mbcE24030101. doi: 10.1091/mbc.E24-03-0101. Online ahead of print. Mol Biol Cell. 2024. PMID: 39718773

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