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Page 1
PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization.
Ito J, Nakamura T, Toyama T, Chen D, Berndt C, Poschmann G, Mourão ASD, Doll S, Suzuki M, Zhang W, Zheng J, Trümbach D, Yamada N, Ono K, Yazaki M, Kawai Y, Arisawa M, Ohsaki Y, Shirakawa H, Wahida A, Proneth B, Saito Y, Nakagawa K, Mishima E, Conrad M. Ito J, et al. Among authors: mourao asd. Mol Cell. 2024 Dec 5;84(23):4629-4644.e9. doi: 10.1016/j.molcel.2024.10.028. Epub 2024 Nov 14. Mol Cell. 2024. PMID: 39547222 Free article.
FSP1 is a glutathione-independent ferroptosis suppressor.
Doll S, Freitas FP, Shah R, Aldrovandi M, da Silva MC, Ingold I, Goya Grocin A, Xavier da Silva TN, Panzilius E, Scheel CH, Mourão A, Buday K, Sato M, Wanninger J, Vignane T, Mohana V, Rehberg M, Flatley A, Schepers A, Kurz A, White D, Sauer M, Sattler M, Tate EW, Schmitz W, Schulze A, O'Donnell V, Proneth B, Popowicz GM, Pratt DA, Angeli JPF, Conrad M. Doll S, et al. Nature. 2019 Nov;575(7784):693-698. doi: 10.1038/s41586-019-1707-0. Epub 2019 Oct 21. Nature. 2019. PMID: 31634899
A non-canonical vitamin K cycle is a potent ferroptosis suppressor.
Mishima E, Ito J, Wu Z, Nakamura T, Wahida A, Doll S, Tonnus W, Nepachalovich P, Eggenhofer E, Aldrovandi M, Henkelmann B, Yamada KI, Wanninger J, Zilka O, Sato E, Feederle R, Hass D, Maida A, Mourão ASD, Linkermann A, Geissler EK, Nakagawa K, Abe T, Fedorova M, Proneth B, Pratt DA, Conrad M. Mishima E, et al. Among authors: mourao asd. Nature. 2022 Aug;608(7924):778-783. doi: 10.1038/s41586-022-05022-3. Epub 2022 Aug 3. Nature. 2022. PMID: 35922516 Free PMC article.
DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition.
Mishima E, Nakamura T, Zheng J, Zhang W, Mourão ASD, Sennhenn P, Conrad M. Mishima E, et al. Among authors: mourao asd. Nature. 2023 Jul;619(7968):E9-E18. doi: 10.1038/s41586-023-06269-0. Epub 2023 Jul 5. Nature. 2023. PMID: 37407687 No abstract available.
Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation.
Nakamura T, Mishima E, Yamada N, Mourão ASD, Trümbach D, Doll S, Wanninger J, Lytton E, Sennhenn P, Nishida Xavier da Silva T, Angeli JPF, Sattler M, Proneth B, Conrad M. Nakamura T, et al. Among authors: mourao asd. Nat Struct Mol Biol. 2023 Nov;30(11):1806-1815. doi: 10.1038/s41594-023-01136-y. Epub 2023 Nov 13. Nat Struct Mol Biol. 2023. PMID: 37957306 Free PMC article.
A tangible method to assess native ferroptosis suppressor activity.
Nakamura T, Ito J, Mourão ASD, Wahida A, Nakagawa K, Mishima E, Conrad M. Nakamura T, et al. Among authors: mourao asd. Cell Rep Methods. 2024 Mar 25;4(3):100710. doi: 10.1016/j.crmeth.2024.100710. Epub 2024 Feb 24. Cell Rep Methods. 2024. PMID: 38401540 Free PMC article.
Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses.
Napolitano V, Dabrowska A, Schorpp K, Mourão A, Barreto-Duran E, Benedyk M, Botwina P, Brandner S, Bostock M, Chykunova Y, Czarna A, Dubin G, Fröhlich T, Hölscher M, Jedrysik M, Matsuda A, Owczarek K, Pachota M, Plettenburg O, Potempa J, Rothenaigner I, Schlauderer F, Slysz K, Szczepanski A, Greve-Isdahl Mohn K, Blomberg B, Sattler M, Hadian K, Popowicz GM, Pyrc K. Napolitano V, et al. Cell Chem Biol. 2022 May 19;29(5):774-784.e8. doi: 10.1016/j.chembiol.2021.11.006. Epub 2022 Jan 11. Cell Chem Biol. 2022. PMID: 35021060 Free PMC article.
26 results