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ONC206, an imipridone derivative, demonstrates anti-colorectal cancer activity against stem/progenitor cells in 3D cell cultures and in patient-derived organoids.
Monzer A, Ghamlouche F, Wakimian K, Ballout F, Al Bitar S, Yehya A, Kanso M, Saheb N, Tawil A, Doughan S, Hussein M, Mukherji D, Faraj W, Allen JE, Prabhu VV, Abou-Antoun T, Gali-Muhtasib H, Abou-Kheir W. Monzer A, et al. Among authors: prabhu vv. Pharmacol Rep. 2024 Nov 18. doi: 10.1007/s43440-024-00676-4. Online ahead of print. Pharmacol Rep. 2024. PMID: 39551911
Imipridones inhibit tumor growth and improve survival in an orthotopic liver metastasis mouse model of human uveal melanoma.
Chattopadhyay C, Roszik J, Bhattacharya R, Alauddin M, Mahmud I, Yadugiri S, Ali MM, Khan FS, Prabhu VV, Lorenzi PL, Wei B, Burton E, Morey RR, Lazcano R, Davies MA, Patel SP, Grimm EA. Chattopadhyay C, et al. Among authors: prabhu vv. Br J Cancer. 2024 Oct 11. doi: 10.1038/s41416-024-02866-6. Online ahead of print. Br J Cancer. 2024. PMID: 39394450
Imipridones inhibit tumor growth and improve survival in an orthotopic liver metastasis mouse model of human uveal melanoma.
Chattopadhyay C, Roszik J, Bhattacharya R, Alauddin M, Mahmud I, Yadugiri S, Ali MM, Khan FS, Prabhu VV, Lorenzi P, Burton E, Morey RR, Lazcano R, Davies MA, Patel SP, Grimm EA. Chattopadhyay C, et al. Among authors: prabhu vv. bioRxiv [Preprint]. 2024 Jan 15:2024.01.12.575058. doi: 10.1101/2024.01.12.575058. bioRxiv. 2024. Update in: Br J Cancer. 2024 Oct 11. doi: 10.1038/s41416-024-02866-6. PMID: 38293232 Free PMC article. Updated. Preprint.
The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia.
Su Y, Carter JL, Li X, Fukuda Y, Gray A, Lynch J, Edwards H, Ma J, Schreiner P, Polin L, Kushner J, Dzinic SH, Buck SA, Pruett-Miller SM, Hege-Hurrish K, Robinson C, Qiao X, Liu S, Wu S, Wang G, Li J, Allen JE, Prabhu VV, Schimmer AD, Joshi D, Kalhor-Monfared S, Watson IDG, Marcellus R, Isaac MB, Al-Awar R, Taub JW, Lin H, Schuetz JD, Ge Y. Su Y, et al. Among authors: prabhu vv. Cancer Res. 2024 Apr 1;84(7):1084-1100. doi: 10.1158/0008-5472.CAN-23-2659. Cancer Res. 2024. PMID: 38266099 Free PMC article.
96 results