Aguilar-Rodríguez J - Search Results

1

Massively parallel experimental interrogation of natural variants in ancient signaling pathways reveals both purifying selection and local adaptation.

Aguilar-Rodríguez J, Vila J, Chen SA, Razo-Mejia M, Ghosh O, Fraser HB, Jarosz DF, Petrov DA. Aguilar-Rodríguez J, et al. bioRxiv [Preprint]. 2024 Oct 31:2024.10.30.621178. doi: 10.1101/2024.10.30.621178. bioRxiv. 2024. PMID: 39553990 Free PMC article. Preprint.

2

The Hsp90 Molecular Chaperone as a Global Modifier of the Genotype-Phenotype-Fitness Map: An Evolutionary Perspective.

Aguilar-Rodríguez J, Jakobson CM, Jarosz DF. Aguilar-Rodríguez J, et al. J Mol Biol. 2024 Dec 1;436(23):168846. doi: 10.1016/j.jmb.2024.168846. Epub 2024 Oct 29. J Mol Biol. 2024. PMID: 39481633 Review.

3

Hsp90 shapes adaptation by controlling the fitness consequences of regulatory variation.

Jakobson CM, Aguilar-Rodríguez J, Jarosz DF. Jakobson CM, et al. Among authors: aguilar rodriguez j. bioRxiv [Preprint]. 2023 Nov 2:2023.10.30.564848. doi: 10.1101/2023.10.30.564848. bioRxiv. 2023. PMID: 37961536 Free PMC article. Preprint.

4

Molecular Chaperones Accelerate the Evolution of Their Protein Clients in Yeast.

Alvarez-Ponce D, Aguilar-Rodríguez J, Fares MA. Alvarez-Ponce D, et al. Among authors: aguilar rodriguez j. Genome Biol Evol. 2019 Aug 1;11(8):2360-2375. doi: 10.1093/gbe/evz147. Genome Biol Evol. 2019. PMID: 31297528 Free PMC article.

5

Chaperonin overproduction and metabolic erosion caused by mutation accumulation in Escherichia coli.

Aguilar-Rodríguez J, Fares MA, Wagner A. Aguilar-Rodríguez J, et al. FEMS Microbiol Lett. 2019 May 1;366(10):fnz121. doi: 10.1093/femsle/fnz121. FEMS Microbiol Lett. 2019. PMID: 31150542

6

Metabolic Determinants of Enzyme Evolution in a Genome-Scale Bacterial Metabolic Network.

Aguilar-Rodríguez J, Wagner A. Aguilar-Rodríguez J, et al. Genome Biol Evol. 2018 Nov 1;10(11):3076-3088. doi: 10.1093/gbe/evy234. Genome Biol Evol. 2018. PMID: 30351420 Free PMC article.

7

High mutation rates limit evolutionary adaptation in Escherichia coli.

Sprouffske K, Aguilar-Rodríguez J, Sniegowski P, Wagner A. Sprouffske K, et al. Among authors: aguilar rodriguez j. PLoS Genet. 2018 Apr 27;14(4):e1007324. doi: 10.1371/journal.pgen.1007324. eCollection 2018 Apr. PLoS Genet. 2018. PMID: 29702649 Free PMC article.

8

The architecture of an empirical genotype-phenotype map.

Aguilar-Rodríguez J, Peel L, Stella M, Wagner A, Payne JL. Aguilar-Rodríguez J, et al. Evolution. 2018 Jun;72(6):1242-1260. doi: 10.1111/evo.13487. Epub 2018 May 25. Evolution. 2018. PMID: 29676774 Free PMC article.

9

A thousand empirical adaptive landscapes and their navigability.

Aguilar-Rodríguez J, Payne JL, Wagner A. Aguilar-Rodríguez J, et al. Nat Ecol Evol. 2017 Jan 23;1(2):45. doi: 10.1038/s41559-016-0045. Nat Ecol Evol. 2017. PMID: 28812623

10

The Molecular Chaperone DnaK Is a Source of Mutational Robustness.

Aguilar-Rodríguez J, Sabater-Muñoz B, Montagud-Martínez R, Berlanga V, Alvarez-Ponce D, Wagner A, Fares MA. Aguilar-Rodríguez J, et al. Genome Biol Evol. 2016 Oct 5;8(9):2979-2991. doi: 10.1093/gbe/evw176. Genome Biol Evol. 2016. PMID: 27497316 Free PMC article.

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