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A systematic search for RNA structural switches across the human transcriptome.
Khoroshkin M, Asarnow D, Zhou S, Navickas A, Winters A, Goudreau J, Zhou SK, Yu J, Palka C, Fish L, Borah A, Yousefi K, Carpenter C, Ansel KM, Cheng Y, Gilbert LA, Goodarzi H. Khoroshkin M, et al. Among authors: gilbert la. Nat Methods. 2024 Sep;21(9):1634-1645. doi: 10.1038/s41592-024-02335-1. Epub 2024 Jul 16. Nat Methods. 2024. PMID: 39014073 Free PMC article.
Engineered CRISPR-Cas12a for higher-order combinatorial chromatin perturbations.
Hsiung CC, Wilson CM, Sambold NA, Dai R, Chen Q, Teyssier N, Misiukiewicz S, Arab A, O'Loughlin T, Cofsky JC, Shi J, Gilbert LA. Hsiung CC, et al. Among authors: gilbert la. Nat Biotechnol. 2024 May 17. doi: 10.1038/s41587-024-02224-0. Online ahead of print. Nat Biotechnol. 2024. PMID: 38760567
Improving prime editing with an endogenous small RNA-binding protein.
Yan J, Oyler-Castrillo P, Ravisankar P, Ward CC, Levesque S, Jing Y, Simpson D, Zhao A, Li H, Yan W, Goudy L, Schmidt R, Solley SC, Gilbert LA, Chan MM, Bauer DE, Marson A, Parsons LR, Adamson B. Yan J, et al. Among authors: gilbert la. Nature. 2024 Apr;628(8008):639-647. doi: 10.1038/s41586-024-07259-6. Epub 2024 Apr 3. Nature. 2024. PMID: 38570691 Free PMC article.
ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway in breast cancer.
Wang S, Böhnert V, Joseph AJ, Sudaryo V, Skariah G, Swinderman JT, Yu FB, Subramanyam V, Wolf DM, Lyu X, Gilbert LA, Van't Veer LJ, Goodarzi H, Li L. Wang S, et al. Among authors: gilbert la. Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2313693120. doi: 10.1073/pnas.2313693120. Epub 2023 Dec 20. Proc Natl Acad Sci U S A. 2023. PMID: 38117852 Free PMC article.
Base-editing mutagenesis maps alleles to tune human T cell functions.
Schmidt R, Ward CC, Dajani R, Armour-Garb Z, Ota M, Allain V, Hernandez R, Layeghi M, Xing G, Goudy L, Dorovskyi D, Wang C, Chen YY, Ye CJ, Shy BR, Gilbert LA, Eyquem J, Pritchard JK, Dodgson SE, Marson A. Schmidt R, et al. Among authors: gilbert la. Nature. 2024 Jan;625(7996):805-812. doi: 10.1038/s41586-023-06835-6. Epub 2023 Dec 13. Nature. 2024. PMID: 38093011 Free PMC article.
92 results