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Page 1
Dietary control of peripheral adipose storage capacity through membrane lipid remodelling.
Tol MJ, Shimanaka Y, Bedard AH, Sapia J, Cui L, Colaço-Gaspar M, Hofer P, Ferrari A, Qian K, Kennelly JP, Lee SD, Gao Y, Xiao X, Gao J, Mack JJ, Weston TA, Pan C, Lusis AJ, Williams KJ, Su B, Pike DP, Reed A, Milosevich N, Cravatt BF, Arita M, Young SG, Ford DA, Zechner R, Vanni S, Tontonoz P. Tol MJ, et al. Among authors: tontonoz p. bioRxiv [Preprint]. 2024 Oct 29:2024.10.25.620374. doi: 10.1101/2024.10.25.620374. bioRxiv. 2024. PMID: 39554041 Free PMC article. Preprint.
Transcription factor PATZ1 promotes adipogenesis by controlling promoter regulatory loci of adipogenic factors.
Patel S, Ganbold K, Cho CH, Siddiqui J, Yildiz R, Sparman N, Sadeh S, Nguyen CM, Wang J, Whitelegge JP, Fried SK, Waki H, Villanueva CJ, Seldin MM, Sakaguchi S, Ellmeier W, Tontonoz P, Rajbhandari P. Patel S, et al. Among authors: tontonoz p. Nat Commun. 2024 Oct 2;15(1):8533. doi: 10.1038/s41467-024-52917-y. Nat Commun. 2024. PMID: 39358382 Free PMC article.
Cholesterol binding to VCAM-1 promotes vascular inflammation.
Kennelly JP, Xiao X, Gao Y, Kim S, Hong SG, Villanueva M, Ferrari A, Vanharanta L, Nguyen A, Nagari RT, Burton NR, Tol MJ, Becker AP, Lee MJ, Ikonen E, Backus KM, Mack JJ, Tontonoz P. Kennelly JP, et al. Among authors: tontonoz p. bioRxiv [Preprint]. 2024 Sep 18:2024.09.17.613543. doi: 10.1101/2024.09.17.613543. bioRxiv. 2024. PMID: 39345495 Free PMC article. Preprint.
Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health.
Lockhart SM, Muso M, Zvetkova I, Lam BYH, Ferrari A, Schoenmakers E, Duckett K, Leslie J, Collins A, Romartínez-Alonso B, Tadross JA, Jia R, Gardner EJ, Kentistou K, Zhao Y, Day F, Mörseburg A, Rainbow K, Rimmington D, Mastantuoni M, Harrison J, Nus M, Guma'a K, Sherratt-Mayhew S, Jiang X, Smith KR, Paul DS, Jenkins B, Koulman A, Pietzner M, Langenberg C, Wareham N, Yeo GS, Chatterjee K, Schwabe J, Oakley F, Mann DA, Tontonoz P, Coll AP, Ong K, Perry JRB, O'Rahilly S. Lockhart SM, et al. Among authors: tontonoz p. Nat Metab. 2024 Oct;6(10):1922-1938. doi: 10.1038/s42255-024-01126-4. Epub 2024 Sep 25. Nat Metab. 2024. PMID: 39322746 Free PMC article.
PUFAs regulate SREBP1c through phosphorylation of Insig2.
Xiao X, Tontonoz P. Xiao X, et al. Among authors: tontonoz p. Proc Natl Acad Sci U S A. 2024 Oct;121(40):e2416363121. doi: 10.1073/pnas.2416363121. Epub 2024 Sep 23. Proc Natl Acad Sci U S A. 2024. PMID: 39312672 No abstract available.
Low MBOAT7 expression, a genetic risk for MASH, promotes a profibrotic pathway involving hepatocyte TAZ upregulation.
Moore MP, Wang X, Kennelly JP, Shi H, Ishino Y, Kano K, Aoki J, Cherubini A, Ronzoni L, Guo X, Chalasani NP, Khalid S, Saleheen D, Mitsche MA, Rotter JI, Yates KP, Valenti L, Kono N, Tontonoz P, Tabas I. Moore MP, et al. Among authors: tontonoz p. Hepatology. 2024 May 22. doi: 10.1097/HEP.0000000000000933. Online ahead of print. Hepatology. 2024. PMID: 38776184
272 results