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Multimodal perturbation analyses of cyclin-dependent kinases reveal a network of synthetic lethalities associated with cell-cycle regulation and transcriptional regulation.
Ford K, Munson BP, Fong SH, Panwala R, Chu WK, Rainaldi J, Plongthongkum N, Arunachalam V, Kostrowicki J, Meluzzi D, Kreisberg JF, Jensen-Pergakes K, VanArsdale T, Paul T, Tamayo P, Zhang K, Bienkowska J, Mali P, Ideker T. Ford K, et al. Sci Rep. 2023 May 11;13(1):7678. doi: 10.1038/s41598-023-33329-2. Sci Rep. 2023. PMID: 37169829 Free PMC article.
Functional Genomics via CRISPR-Cas.
Ford K, McDonald D, Mali P. Ford K, et al. J Mol Biol. 2019 Jan 4;431(1):48-65. doi: 10.1016/j.jmb.2018.06.034. Epub 2018 Jun 28. J Mol Biol. 2019. PMID: 29959923 Free PMC article. Review.
A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC.
Goto Y, Koshizuka K, Ando T, Izumi H, Wu X, Sato K, Ishikawa T, Ford K, Feng X, Wang Z, Arang N, Allevato MM, Kishore A, Mali P, Gutkind JS. Goto Y, et al. Among authors: ford k. Cancer Res Commun. 2024 Jul 1;4(7):1850-1862. doi: 10.1158/2767-9764.CRC-24-0247. Cancer Res Commun. 2024. PMID: 38954773 Free PMC article.
Interface-guided phenotyping of coding variants in the transcription factor RUNX1.
Ozturk K, Panwala R, Sheen J, Ford K, Jayne N, Portell A, Zhang DE, Hutter S, Haferlach T, Ideker T, Mali P, Carter H. Ozturk K, et al. Among authors: ford k. Cell Rep. 2024 Jul 23;43(7):114436. doi: 10.1016/j.celrep.2024.114436. Epub 2024 Jul 4. Cell Rep. 2024. PMID: 38968069 Free PMC article.
Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma.
Paradis JS, Acosta M, Saddawi-Konefka R, Kishore A, Gomes F, Arang N, Tiago M, Coma S, Lubrano S, Wu X, Ford K, Day CP, Merlino G, Mali P, Pachter JA, Sato T, Aplin AE, Gutkind JS. Paradis JS, et al. Among authors: ford k. Clin Cancer Res. 2021 Jun 1;27(11):3190-3200. doi: 10.1158/1078-0432.CCR-20-3363. Epub 2021 Feb 10. Clin Cancer Res. 2021. PMID: 33568347 Free PMC article.
Interface-guided phenotyping of coding variants in the transcription factor RUNX1 with SEUSS.
Ozturk K, Panwala R, Sheen J, Ford K, Payne N, Zhang DE, Hutter S, Haferlach T, Ideker T, Mali P, Carter H. Ozturk K, et al. Among authors: ford k. bioRxiv [Preprint]. 2023 Aug 4:2023.08.03.551876. doi: 10.1101/2023.08.03.551876. bioRxiv. 2023. Update in: Cell Rep. 2024 Jul 23;43(7):114436. doi: 10.1016/j.celrep.2024.114436 PMID: 37577681 Free PMC article. Updated. Preprint.
Correction: Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma.
Paradis JS, Acosta M, Saddawi-Konefka R, Kishore A, Lubrano S, Gomes F, Arang N, Tiago M, Coma S, Wu X, Ford K, Day CP, Merlino G, Mali P, Pachter JA, Sato T, Aplin AE, Gutkind JS. Paradis JS, et al. Among authors: ford k. Clin Cancer Res. 2021 Aug 15;27(16):4664. doi: 10.1158/1078-0432.CCR-21-2433. Clin Cancer Res. 2021. PMID: 34389658 No abstract available.
1,137 results