Tharp JM - Search Results

1

Efficient suppression of premature termination codons with alanine by engineered chimeric pyrrolysine tRNAs.

Awawdeh A, Tapia A, Alshawi SA, Dawodu O, Gaier SA, Specht C, Beaudoin JD, Tharp JM, Vargas-Rodriguez O. Awawdeh A, et al. Among authors: tharp jm. Nucleic Acids Res. 2024 Dec 11;52(22):14244-14259. doi: 10.1093/nar/gkae1048. Nucleic Acids Res. 2024. PMID: 39558163 Free PMC article.

2

tRNA shape is an identity element for an archaeal pyrrolysyl-tRNA synthetase from the human gut.

Krahn N, Zhang J, Melnikov SV, Tharp JM, Villa A, Patel A, Howard RJ, Gabir H, Patel TR, Stetefeld J, Puglisi J, Söll D. Krahn N, et al. Among authors: tharp jm. Nucleic Acids Res. 2024 Jan 25;52(2):513-524. doi: 10.1093/nar/gkad1188. Nucleic Acids Res. 2024. PMID: 38100361 Free PMC article.

3

Reprogramming Initiator and Nonsense Codons to Simultaneously Install Three Distinct Noncanonical Amino Acids into Proteins in E. coli.

Jiang HK, Tharp JM. Jiang HK, et al. Among authors: tharp jm. Methods Mol Biol. 2023;2676:101-116. doi: 10.1007/978-1-0716-3251-2_7. Methods Mol Biol. 2023. PMID: 37277627

4

Split aminoacyl-tRNA synthetases for proximity-induced stop codon suppression.

Jiang HK, Ambrose NL, Chung CZ, Wang YS, Söll D, Tharp JM. Jiang HK, et al. Among authors: tharp jm. Proc Natl Acad Sci U S A. 2023 Feb 21;120(8):e2219758120. doi: 10.1073/pnas.2219758120. Epub 2023 Feb 14. Proc Natl Acad Sci U S A. 2023. PMID: 36787361 Free PMC article.

5

Novel Regioselective Approach to Cyclize Phage-Displayed Peptides in Combination with Epitope-Directed Selection to Identify a Potent Neutralizing Macrocyclic Peptide for SARS-CoV-2.

Hampton JT, Lalonde TJ, Tharp JM, Kurra Y, Alugubelli YR, Roundy CM, Hamer GL, Xu S, Liu WR. Hampton JT, et al. Among authors: tharp jm. ACS Chem Biol. 2022 Oct 21;17(10):2911-2922. doi: 10.1021/acschembio.2c00565. Epub 2022 Sep 29. ACS Chem Biol. 2022. PMID: 36174018 Free PMC article.

6

Ancestral archaea expanded the genetic code with pyrrolysine.

Guo LT, Amikura K, Jiang HK, Mukai T, Fu X, Wang YS, O'Donoghue P, Söll D, Tharp JM. Guo LT, et al. Among authors: tharp jm. J Biol Chem. 2022 Nov;298(11):102521. doi: 10.1016/j.jbc.2022.102521. Epub 2022 Sep 22. J Biol Chem. 2022. PMID: 36152750 Free PMC article.

7

Directed Evolution of Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetase Generates a Hyperactive and Highly Selective Variant.

Fischer JT, Söll D, Tharp JM. Fischer JT, et al. Among authors: tharp jm. Front Mol Biosci. 2022 Mar 9;9:850613. doi: 10.3389/fmolb.2022.850613. eCollection 2022. Front Mol Biosci. 2022. PMID: 35372501 Free PMC article.

8

Initiating protein synthesis with noncanonical monomers in vitro and in vivo.

Tharp JM, Walker JA, Söll D, Schepartz A. Tharp JM, et al. Methods Enzymol. 2021;656:495-519. doi: 10.1016/bs.mie.2021.05.002. Epub 2021 Jun 2. Methods Enzymol. 2021. PMID: 34325796 Free PMC article.

9

Genetic Encoding of Three Distinct Noncanonical Amino Acids Using Reprogrammed Initiator and Nonsense Codons.

Tharp JM, Vargas-Rodriguez O, Schepartz A, Söll D. Tharp JM, et al. ACS Chem Biol. 2021 Apr 16;16(4):766-774. doi: 10.1021/acschembio.1c00120. Epub 2021 Mar 16. ACS Chem Biol. 2021. PMID: 33723984 Free PMC article.

10

An amber obligate active site-directed ligand evolution technique for phage display.

Tharp JM, Hampton JT, Reed CA, Ehnbom A, Chen PC, Morse JS, Kurra Y, Pérez LM, Xu S, Liu WR. Tharp JM, et al. Nat Commun. 2020 Mar 13;11(1):1392. doi: 10.1038/s41467-020-15057-7. Nat Commun. 2020. PMID: 32170178 Free PMC article.

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