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SARS-CoV-2 evolution balances conflicting roles of N protein phosphorylation.
Syed AM, Ciling A, Chen IP, Carlson CR, Adly AN, Martin HS, Taha TY, Khalid MM, Price N, Bouhaddou M, Ummadi MR, Moen JM, Krogan NJ, Morgan DO, Ott M, Doudna JA. Syed AM, et al. Among authors: chen ip. PLoS Pathog. 2024 Nov 21;20(11):e1012741. doi: 10.1371/journal.ppat.1012741. eCollection 2024 Nov. PLoS Pathog. 2024. PMID: 39571001 Free PMC article.
Rapid assessment of SARS-CoV-2-evolved variants using virus-like particles.
Syed AM, Taha TY, Tabata T, Chen IP, Ciling A, Khalid MM, Sreekumar B, Chen PY, Hayashi JM, Soczek KM, Ott M, Doudna JA. Syed AM, et al. Among authors: chen py, chen ip. Science. 2021 Dec 24;374(6575):1626-1632. doi: 10.1126/science.abl6184. Epub 2021 Nov 4. Science. 2021. PMID: 34735219 Free PMC article.
Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles.
Syed AM, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Spraggon L, Taha TY, Tabata T, Chen IP, Ott M, Doudna JA. Syed AM, et al. Among authors: chen py, chen ip. medRxiv [Preprint]. 2022 Jan 2:2021.12.20.21268048. doi: 10.1101/2021.12.20.21268048. medRxiv. 2022. Update in: Proc Natl Acad Sci U S A. 2022 Aug 2;119(31):e2200592119. doi: 10.1073/pnas.2200592119 PMID: 34981067 Free PMC article. Updated. Preprint.
Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination.
Suryawanshi RK, Chen IP, Ma T, Syed AM, Brazer N, Saldhi P, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Montano M, Gascon R, Tsou CL, Garcia-Knight MA, Sotomayor-Gonzalez A, Servellita V, Gliwa A, Nguyen J, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Soveg FW, George AF, Fang X, Maishan M, Matthay M, Morris MK, Wadford D, Hanson C, Greene WC, Andino R, Spraggon L, Roan NR, Chiu CY, Doudna JA, Ott M. Suryawanshi RK, et al. Among authors: chen py, chen ip. Nature. 2022 Jul;607(7918):351-355. doi: 10.1038/s41586-022-04865-0. Epub 2022 May 18. Nature. 2022. PMID: 35584773 Free PMC article.
Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2.
Chen IP, Longbotham JE, McMahon S, Suryawanshi RK, Khalid MM, Taha TY, Tabata T, Hayashi JM, Soveg FW, Carlson-Stevermer J, Gupta M, Zhang MY, Lam VL, Li Y, Yu Z, Titus EW, Diallo A, Oki J, Holden K, Krogan N, Fujimori DG, Ott M. Chen IP, et al. Cell Rep. 2022 Jul 19;40(3):111088. doi: 10.1016/j.celrep.2022.111088. Epub 2022 Jun 27. Cell Rep. 2022. PMID: 35839775 Free PMC article.
Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles.
Syed AM, Ciling A, Taha TY, Chen IP, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Suryawanshi R, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Spraggon L, Tabata T, Ott M, Doudna JA. Syed AM, et al. Among authors: chen py, chen ip. Proc Natl Acad Sci U S A. 2022 Aug 2;119(31):e2200592119. doi: 10.1073/pnas.2200592119. Epub 2022 Jul 19. Proc Natl Acad Sci U S A. 2022. PMID: 35858386 Free PMC article.
SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein.
Walter M, Chen IP, Vallejo-Gracia A, Kim IJ, Bielska O, Lam VL, Hayashi JM, Cruz A, Shah S, Soveg FW, Gross JD, Krogan NJ, Jerome KR, Schilling B, Ott M, Verdin E. Walter M, et al. Among authors: chen ip. PLoS Pathog. 2022 Sep 12;18(9):e1010811. doi: 10.1371/journal.ppat.1010811. eCollection 2022 Sep. PLoS Pathog. 2022. PMID: 36095012 Free PMC article.
Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA.1 variant through NSP6.
Taha TY, Chen IP, Hayashi JM, Tabata T, Walcott K, Kimmerly GR, Syed AM, Ciling A, Suryawanshi RK, Martin HS, Bach BH, Tsou CL, Montano M, Khalid MM, Sreekumar BK, Renuka Kumar G, Wyman S, Doudna JA, Ott M. Taha TY, et al. Among authors: chen ip. Nat Commun. 2023 Apr 21;14(1):2308. doi: 10.1038/s41467-023-37787-0. Nat Commun. 2023. PMID: 37085489 Free PMC article.
A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo.
Taha TY, Suryawanshi RK, Chen IP, Correy GJ, McCavitt-Malvido M, O'Leary PC, Jogalekar MP, Diolaiti ME, Kimmerly GR, Tsou CL, Gascon R, Montano M, Martinez-Sobrido L, Krogan NJ, Ashworth A, Fraser JS, Ott M. Taha TY, et al. Among authors: chen ip. PLoS Pathog. 2023 Aug 31;19(8):e1011614. doi: 10.1371/journal.ppat.1011614. eCollection 2023 Aug. PLoS Pathog. 2023. PMID: 37651466 Free PMC article.
113 results