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Large-scale investigation for antimicrobial activity reveals novel defensive species across the healthy skin microbiome.
Nguyen UT, Salamzade R, Sandstrom S, Swaney MH, Townsend L, Wu SY, Cheong JZA, Sardina JA, Ludwikoski I, Rybolt M, Wan H, Carlson C, Zarnowski R, Andes D, Currie C, Kalan L. Nguyen UT, et al. Among authors: zarnowski r. bioRxiv [Preprint]. 2024 Nov 4:2024.11.04.621544. doi: 10.1101/2024.11.04.621544. bioRxiv. 2024. PMID: 39574598 Free PMC article. Preprint.
Analogues of the anti-malaria drug mefloquine have broad spectrum antifungal activity and are efficacious in a model of disseminated Candida auris infection.
Guin S, Montoya MC, Wang X, Zarnowski R, Andes DR, Meyers MJ, Williams NS, Krysan DJ. Guin S, et al. Among authors: zarnowski r. bioRxiv [Preprint]. 2024 Aug 30:2024.08.29.610379. doi: 10.1101/2024.08.29.610379. bioRxiv. 2024. Update in: Antimicrob Agents Chemother. 2024 Nov 6;68(11):e0130124. doi: 10.1128/aac.01301-24 PMID: 39257751 Free PMC article. Updated. Preprint.
Systematic analysis of the Candida albicans kinome reveals environmentally contingent protein kinase-mediated regulation of filamentation and biofilm formation in vitro and in vivo.
Kramara J, Kim M-J, Ollinger TL, Ristow LC, Wakade RS, Zarnowski R, Wellington M, Andes DR, Mitchell AG, Krysan DJ. Kramara J, et al. Among authors: zarnowski r. mBio. 2024 Aug 14;15(8):e0124924. doi: 10.1128/mbio.01249-24. Epub 2024 Jul 1. mBio. 2024. PMID: 38949302 Free PMC article.
Biofilm-associated metabolism via ERG251 in Candida albicans.
Xiong L, Pereira De Sa N, Zarnowski R, Huang MY, Mota Fernandes C, Lanni F, Andes DR, Del Poeta M, Mitchell AP. Xiong L, et al. Among authors: zarnowski r. PLoS Pathog. 2024 May 13;20(5):e1012225. doi: 10.1371/journal.ppat.1012225. eCollection 2024 May. PLoS Pathog. 2024. PMID: 38739655 Free PMC article.
Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences.
Müller R, König A, Groth S, Zarnowski R, Visser C, Handrianz T, Maufrais C, Krüger T, Himmel M, Lee S, Priest EL, Yildirim D, Richardson JP, Blango MG, Bougnoux ME, Kniemeyer O, d'Enfert C, Brakhage AA, Andes DR, Trümper V, Nehls C, Kasper L, Mogavero S, Gutsmann T, Naglik JR, Allert S, Hube B. Müller R, et al. Among authors: zarnowski r. Nat Microbiol. 2024 Mar;9(3):669-683. doi: 10.1038/s41564-024-01606-z. Epub 2024 Feb 22. Nat Microbiol. 2024. PMID: 38388771
Candida albicans extracellular vesicles trigger type I IFN signalling via cGAS and STING.
Brown Harding H, Kwaku GN, Reardon CM, Khan NS, Zamith-Miranda D, Zarnowski R, Tam JM, Bohaen CK, Richey L, Mosallanejad K, Crossen AJ, Reedy JL, Ward RA, Vargas-Blanco DA, Basham KJ, Bhattacharyya RP, Nett JE, Mansour MK, van de Veerdonk FL, Kumar V, Kagan JC, Andes DR, Nosanchuk JD, Vyas JM. Brown Harding H, et al. Among authors: zarnowski r. Nat Microbiol. 2024 Jan;9(1):95-107. doi: 10.1038/s41564-023-01546-0. Epub 2024 Jan 2. Nat Microbiol. 2024. PMID: 38168615 Free PMC article.
Liposomal formulation of a new antifungal hybrid compound provides protection against Candida auris in the ex vivo skin colonization model.
Jaromin A, Zarnowski R, Markowski A, Zagórska A, Johnson CJ, Etezadi H, Kihara S, Mota-Santiago P, Nett JE, Boyd BJ, Andes DR. Jaromin A, et al. Among authors: zarnowski r. Antimicrob Agents Chemother. 2024 Jan 10;68(1):e0095523. doi: 10.1128/aac.00955-23. Epub 2023 Dec 11. Antimicrob Agents Chemother. 2024. PMID: 38092678 Free PMC article.
82 results