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Designed miniproteins potently inhibit and protect against MERS-CoV.
Ragotte RJ, Tortorici MA, Catanzaro NJ, Addetia A, Coventry B, Froggatt HM, Lee J, Stewart C, Brown JT, Goreshnik I, Sims JN, Milles LF, Wicky BIM, Glögl M, Gerben S, Kang A, Bera AK, Sharkey W, Schäfer A, Baric RS, Baker D, Veesler D. Ragotte RJ, et al. Among authors: baker d. bioRxiv [Preprint]. 2024 Nov 4:2024.11.03.621760. doi: 10.1101/2024.11.03.621760. bioRxiv. 2024. PMID: 39574666 Free PMC article. Preprint.
Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies.
Edman NI, Redler RL, Phal A, Schlichthaerle T, Srivatsan SR, Etemadi A, An SJ, Favor A, Ehnes D, Li Z, Praetorius F, Gordon M, Yang W, Coventry B, Hicks DR, Cao L, Bethel N, Heine P, Murray A, Gerben S, Carter L, Miranda M, Negahdari B, Lee S, Trapnell C, Stewart L, Ekiert DC, Schlessinger J, Shendure J, Bhabha G, Ruohola-Baker H, Baker D. Edman NI, et al. Among authors: baker d. bioRxiv [Preprint]. 2023 Mar 15:2023.03.14.532666. doi: 10.1101/2023.03.14.532666. bioRxiv. 2023. Update in: Cell. 2024 Jul 11;187(14):3726-3740.e43. doi: 10.1016/j.cell.2024.05.025 PMID: 36993355 Free PMC article. Updated. Preprint.
Genetic manipulation of candidate phyla radiation bacteria provides functional insights into microbial dark matter.
Wang Y, Gallagher LA, Andrade PA, Liu A, Humphreys IR, Turkarslan S, Cutler KJ, Arrieta-Ortiz ML, Li Y, Radey MC, McLean JS, Cong Q, Baker D, Baliga NS, Peterson SB, Mougous JD. Wang Y, et al. Among authors: baker d. bioRxiv [Preprint]. 2023 May 11:2023.05.02.539146. doi: 10.1101/2023.05.02.539146. bioRxiv. 2023. Update in: Cell. 2023 Oct 26;186(22):4803-4817.e13. doi: 10.1016/j.cell.2023.08.017 PMID: 37205512 Free PMC article. Updated. Preprint.
Hierarchical design of pseudosymmetric protein nanoparticles.
Dowling QM, Park YJ, Gerstenmaier N, Yang EC, Wargacki A, Hsia Y, Fries CN, Ravichandran R, Walkey C, Burrell A, Veesler D, Baker D, King NP. Dowling QM, et al. Among authors: baker d. bioRxiv [Preprint]. 2023 Jun 17:2023.06.16.545393. doi: 10.1101/2023.06.16.545393. bioRxiv. 2023. Update in: Nature. 2024 Dec 18. doi: 10.1038/s41586-024-08360-6 PMID: 37398374 Free PMC article. Updated. Preprint.
De novo designed Hsp70 activator dissolves intracellular condensates.
Zhang JZ, Greenwood N, Hernandez J, Cuperus JT, Huang B, Ryder BD, Queitsch C, Gestwicki JE, Baker D. Zhang JZ, et al. Among authors: baker d. bioRxiv [Preprint]. 2023 Sep 19:2023.09.18.558356. doi: 10.1101/2023.09.18.558356. bioRxiv. 2023. PMID: 37781598 Free PMC article. Preprint.
Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies.
Edman NI, Phal A, Redler RL, Schlichthaerle T, Srivatsan SR, Ehnes DD, Etemadi A, An SJ, Favor A, Li Z, Praetorius F, Gordon M, Vincent T, Marchiano S, Blakely L, Lin C, Yang W, Coventry B, Hicks DR, Cao L, Bethel N, Heine P, Murray A, Gerben S, Carter L, Miranda M, Negahdari B, Lee S, Trapnell C, Zheng Y, Murry CE, Schweppe DK, Freedman BS, Stewart L, Ekiert DC, Schlessinger J, Shendure J, Bhabha G, Ruohola-Baker H, Baker D. Edman NI, et al. Among authors: baker d. Cell. 2024 Jul 11;187(14):3726-3740.e43. doi: 10.1016/j.cell.2024.05.025. Epub 2024 Jun 10. Cell. 2024. PMID: 38861993 Free article.
Preclinical proof of principle for orally delivered Th17 antagonist miniproteins.
Berger S, Seeger F, Yu TY, Aydin M, Yang H, Rosenblum D, Guenin-Macé L, Glassman C, Arguinchona L, Sniezek C, Blackstone A, Carter L, Ravichandran R, Ahlrichs M, Murphy M, Pultz IS, Kang A, Bera AK, Stewart L, Garcia KC, Naik S, Spangler JB, Beigel F, Siebeck M, Gropp R, Baker D. Berger S, et al. Among authors: baker d. Cell. 2024 Aug 8;187(16):4305-4317.e18. doi: 10.1016/j.cell.2024.05.052. Epub 2024 Jun 26. Cell. 2024. PMID: 38936360 Free article.
Accurate de novo design of heterochiral protein-protein interactions.
Sun K, Li S, Zheng B, Zhu Y, Wang T, Liang M, Yao Y, Zhang K, Zhang J, Li H, Han D, Zheng J, Coventry B, Cao L, Baker D, Liu L, Lu P. Sun K, et al. Among authors: baker d. Cell Res. 2024 Dec;34(12):846-858. doi: 10.1038/s41422-024-01014-2. Epub 2024 Aug 14. Cell Res. 2024. PMID: 39143121 Free PMC article.
Water, Solute, and Ion Transport in De Novo-Designed Membrane Protein Channels.
Li Y, Harris BS, Li Z, Shi C, Abdullah J, Majumder S, Berhanu S, Vorobieva AA, Myers SK, Hettige J, Baer MD, De Yoreo JJ, Baker D, Noy A. Li Y, et al. Among authors: baker d. ACS Nano. 2025 Jan 21;19(2):2185-2195. doi: 10.1021/acsnano.4c11317. Epub 2024 Dec 23. ACS Nano. 2025. PMID: 39714958
5,820 results