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Page 1
Novel Macrocyclic NLRP3 Inhibitors.
Mesch S, Shannon J, Miller D, MacLeod A, Bouché L, Johnston HJ, Matthews K, Paehler A, Best S, Guba W, Alanine T, Halai R, Charge L, Garside S, Thom S, Incerti-Pradillos C, McPherson C, Carrillo J, St-Gallay S, Rigo P, Schlicht S, Hendrick AG, Lerner C, Piali L, Blaising J, Mracsko EZ, Jaeschke G, Cooper MA. Mesch S, et al. J Med Chem. 2024 Dec 12;67(23):20911-20932. doi: 10.1021/acs.jmedchem.4c01376. Epub 2024 Nov 25. J Med Chem. 2024. PMID: 39585325
Discovery of Orally Available and Brain Penetrant AEP Inhibitors.
Krummenacher D, He W, Kuhn B, Schnider C, Beurier A, Brom V, Sivasothy T, Marty C, Tosstorff A, Hewings DS, Mesch S, Pinard E, Brändlin M, Hochstrasser R, Westwood P, Rothe J, Kronenberger A, Morandi F, Gutbier S, Schuler A, Heer D, Gloria LE, Joedicke L, Rudolph MG, Müller L, Grüninger F, Baumann K, Kaniyappan S, Manevski N, Bartels B. Krummenacher D, et al. Among authors: mesch s. J Med Chem. 2023 Dec 28;66(24):17026-17043. doi: 10.1021/acs.jmedchem.3c01804. Epub 2023 Dec 13. J Med Chem. 2023. PMID: 38090813
Discovery of BAY-390, a Selective CNS Penetrant Chemical Probe as Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonist.
Mesch S, Walter D, Laux-Biehlmann A, Basting D, Flanagan S, Miyatake Ondozabal H, Bäurle S, Pearson C, Jenkins J, Elves P, Hess S, Coelho AM, Rotgeri A, Bothe U, Nawaz S, Zollner TM, Steinmeyer A. Mesch S, et al. J Med Chem. 2023 Jan 26;66(2):1583-1600. doi: 10.1021/acs.jmedchem.2c01830. Epub 2023 Jan 9. J Med Chem. 2023. PMID: 36622903 Free PMC article.
Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis.
Tapmeier TT, Rahmioglu N, Lin J, De Leo B, Obendorf M, Raveendran M, Fischer OM, Bafligil C, Guo M, Harris RA, Hess-Stumpp H, Laux-Biehlmann A, Lowy E, Lunter G, Malzahn J, Martin NG, Martinez FO, Manek S, Mesch S, Montgomery GW, Morris AP, Nagel J, Simmons HA, Brocklebank D, Shang C, Treloar S, Wells G, Becker CM, Oppermann U, Zollner TM, Kennedy SH, Kemnitz JW, Rogers J, Zondervan KT. Tapmeier TT, et al. Among authors: mesch s. Sci Transl Med. 2021 Aug 25;13(608):eabd6469. doi: 10.1126/scitranslmed.abd6469. Sci Transl Med. 2021. PMID: 34433639
Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile.
Werner S, Mesch S, Hillig RC, Ter Laak A, Klint J, Neagoe I, Laux-Biehlmann A, Dahllöf H, Bräuer N, Puetter V, Nubbemeyer R, Schulz S, Bairlein M, Zollner TM, Steinmeyer A. Werner S, et al. Among authors: mesch s. J Med Chem. 2019 Dec 26;62(24):11194-11217. doi: 10.1021/acs.jmedchem.9b01304. Epub 2019 Dec 11. J Med Chem. 2019. PMID: 31746599
From a library of MAG antagonists to nanomolar CD22 ligands.
Mesch S, Lemme K, Wittwer M, Koliwer-Brandl H, Schwardt O, Kelm S, Ernst B. Mesch S, et al. ChemMedChem. 2012 Jan 2;7(1):134-43. doi: 10.1002/cmdc.201100407. Epub 2011 Oct 11. ChemMedChem. 2012. PMID: 21990163
Kinetic and thermodynamic properties of MAG antagonists.
Mesch S, Lemme K, Koliwer-Brandl H, Strasser DS, Schwardt O, Kelm S, Ernst B. Mesch S, et al. Carbohydr Res. 2010 Jul 2;345(10):1348-59. doi: 10.1016/j.carres.2010.03.010. Epub 2010 Mar 16. Carbohydr Res. 2010. PMID: 20359700
13 results