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Staggered immunization with mRNA vaccines encoding SARS-CoV-2 polymerase or spike antigens broadens the T cell epitope repertoire.
Abt ER, Lam AK, Noguchi M, Rashid K, McLaughlin J, Teng PL, Tran W, Cheng D, Nesterenko PA, Mao Z, Creech AL, Burton Sojo G, Jeyachandran AV, Tam YK, Henley JE, Comai L, Pardi N, Arumugaswami V, Witte ON, Radu CG, Wu TT. Abt ER, et al. Among authors: pardi n. Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2406332121. doi: 10.1073/pnas.2406332121. Epub 2024 Nov 26. Proc Natl Acad Sci U S A. 2024. PMID: 39589869 Free PMC article.
Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals.
Cohen AA, Keeffe JR, Schiepers A, Dross SE, Greaney AJ, Rorick AV, Gao H, Gnanapragasam PNP, Fan C, West AP Jr, Ramsingh AI, Erasmus JH, Pata JD, Muramatsu H, Pardi N, Lin PJC, Baxter S, Cruz R, Quintanar-Audelo M, Robb E, Serrano-Amatriain C, Magneschi L, Fotheringham IG, Fuller DH, Victora GD, Bjorkman PJ. Cohen AA, et al. Among authors: pardi n. Cell. 2024 Oct 3;187(20):5554-5571.e19. doi: 10.1016/j.cell.2024.07.052. Epub 2024 Aug 27. Cell. 2024. PMID: 39197450 Free PMC article.
Lymphatic endothelial cell-targeting lipid nanoparticles delivering VEGFC mRNA improve lymphatic function after injury.
Michalaki E, Chin R, Jeong K, Qi Z, Liebman LN, González-Vargas Y, Echeverri ES, Paunovska K, Muramatsu H, Pardi N, Tamburini BJ, Jakus Z, Dahlman JE, Dixon JB. Michalaki E, et al. Among authors: pardi n. bioRxiv [Preprint]. 2024 Jul 31:2024.07.31.605343. doi: 10.1101/2024.07.31.605343. bioRxiv. 2024. PMID: 39131391 Free PMC article. Preprint.
Computationally designed mRNA-launched protein nanoparticle vaccines.
Hendricks GG, Grigoryan L, Navarro MJ, Catanzaro NJ, Hubbard ML, Powers JM, Mattocks M, Treichel C, Walls AC, Lee J, Ellis D, Wang JYJ, Cheng S, Miranda MC, Valdez A, Chao CW, Chan S, Men C, Johnson MR, Hui H, Wu SY, Lujan V, Muramatsu H, Lin PJC, Sung MMH, Tam YK, Leaf EM, Pardi N, Baric RS, Pulendran B, Veesler D, Schäfer A, King NP. Hendricks GG, et al. Among authors: pardi n. bioRxiv [Preprint]. 2024 Jul 23:2024.07.22.604655. doi: 10.1101/2024.07.22.604655. bioRxiv. 2024. PMID: 39091730 Free PMC article. Preprint.
Transient inhibition of type I interferon enhances CD8 + T cell stemness and vaccine protection.
Broomfield BJ, Tan CW, Qin RZ, Duckworth BC, Alvarado C, Dalit L, Chen J, Mackiewicz L, Muramatsu H, Pellegrini M, Rogers KL, Moon WJ, Nutt SL, Davis MJ, Pardi N, Wimmer VC, Groom JR. Broomfield BJ, et al. Among authors: pardi n. bioRxiv [Preprint]. 2024 Jun 28:2024.06.26.600763. doi: 10.1101/2024.06.26.600763. bioRxiv. 2024. PMID: 38979239 Free PMC article. Preprint.
118 results