Wek RC - Search Results

1

Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer.

Cordova RA, Sommers NR, Law AS, Klunk AJ, Brady KE, Goodrich DW, Anthony TG, Brault JJ, Pili R, Wek RC, Staschke KA. Cordova RA, et al. Among authors: wek rc. Sci Signal. 2024 Nov 26;17(864):eadp1375. doi: 10.1126/scisignal.adp1375. Epub 2024 Nov 26. Sci Signal. 2024. PMID: 39591412

2

Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions.

Narasimhan J, Staschke KA, Wek RC. Narasimhan J, et al. Among authors: wek rc. J Biol Chem. 2004 May 28;279(22):22820-32. doi: 10.1074/jbc.M402228200. Epub 2004 Mar 9. J Biol Chem. 2004. PMID: 15010461 Free article.

3

GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis.

Cordova RA, Misra J, Amin PH, Klunk AJ, Damayanti NP, Carlson KR, Elmendorf AJ, Kim HG, Mirek ET, Elzey BD, Miller MJ, Dong XC, Cheng L, Anthony TG, Pili R, Wek RC, Staschke KA. Cordova RA, et al. Among authors: wek rc. Elife. 2022 Sep 15;11:e81083. doi: 10.7554/eLife.81083. Elife. 2022. PMID: 36107759 Free PMC article.

4

Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.

Anthony TG, McDaniel BJ, Byerley RL, McGrath BC, Cavener DR, McNurlan MA, Wek RC. Anthony TG, et al. Among authors: wek rc. J Biol Chem. 2004 Aug 27;279(35):36553-61. doi: 10.1074/jbc.M404559200. Epub 2004 Jun 22. J Biol Chem. 2004. PMID: 15213227 Free article.

5

Coping with stress: eIF2 kinases and translational control.

Wek RC, Jiang HY, Anthony TG. Wek RC, et al. Biochem Soc Trans. 2006 Feb;34(Pt 1):7-11. doi: 10.1042/BST20060007. Biochem Soc Trans. 2006. PMID: 16246168 Review.

6

EXtENDINg beta cell survival by UPRegulating ATF4 translation.

Wek RC, Anthony TG. Wek RC, et al. Cell Metab. 2006 Nov;4(5):333-4. doi: 10.1016/j.cmet.2006.10.006. Cell Metab. 2006. PMID: 17084705 Free article. Review.

7

GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.

Bunpo P, Dudley A, Cundiff JK, Cavener DR, Wek RC, Anthony TG. Bunpo P, et al. Among authors: wek rc. J Biol Chem. 2009 Nov 20;284(47):32742-9. doi: 10.1074/jbc.M109.047910. Epub 2009 Sep 25. J Biol Chem. 2009. PMID: 19783659 Free PMC article.

8

How do tumours adapt to nutrient stress?

Wek RC, Staschke KA. Wek RC, et al. EMBO J. 2010 Jun 16;29(12):1946-7. doi: 10.1038/emboj.2010.110. EMBO J. 2010. PMID: 20551969 Free PMC article. No abstract available.

9

The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase.

Bunpo P, Cundiff JK, Reinert RB, Wek RC, Aldrich CJ, Anthony TG. Bunpo P, et al. Among authors: wek rc. J Nutr. 2010 Nov;140(11):2020-7. doi: 10.3945/jn.110.129197. Epub 2010 Sep 22. J Nutr. 2010. PMID: 20861212 Free PMC article.

10

The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment.

Wilson GJ, Bunpo P, Cundiff JK, Wek RC, Anthony TG. Wilson GJ, et al. Among authors: wek rc. Am J Physiol Endocrinol Metab. 2013 Nov 1;305(9):E1124-33. doi: 10.1152/ajpendo.00080.2013. Epub 2013 Sep 3. Am J Physiol Endocrinol Metab. 2013. PMID: 24002574 Free PMC article.

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