Tu HJ - Search Results

1

Discovery of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitors using an artificial intelligence model and their effects on tau and tubulin dynamics.

Chen JH, Tu HJ, Lin TE, Peng ZX, Wu YW, Yen SC, Sung TY, Hsieh JH, Lee HY, Pan SL, HuangFu WC, Hsu KC. Chen JH, et al. Among authors: tu hj. Biomed Pharmacother. 2024 Dec;181:117688. doi: 10.1016/j.biopha.2024.117688. Epub 2024 Nov 25. Biomed Pharmacother. 2024. PMID: 39591664 Free article.

2

Identification and analysis of a selective DYRK1A inhibitor.

Lin TE, Chao MW, HuangFu WC, Tu HJ, Peng ZX, Su CJ, Sung TY, Hsieh JH, Lee CC, Yang CR, Pan SL, Hsu KC. Lin TE, et al. Among authors: tu hj. Biomed Pharmacother. 2022 Feb;146:112580. doi: 10.1016/j.biopha.2021.112580. Epub 2021 Dec 28. Biomed Pharmacother. 2022. PMID: 34968920 Free article.

3

Identification of selective dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors and their effects on tau and microtubule.

Wu YW, HuangFu WC, Lin TE, Peng CH, Tu HJ, Sung TY, Sung TY, Yen SC, Pan SL, Hsu KC. Wu YW, et al. Among authors: tu hj. Int J Biol Macromol. 2024 Feb;259(Pt 1):129074. doi: 10.1016/j.ijbiomac.2023.129074. Epub 2023 Dec 30. Int J Biol Macromol. 2024. PMID: 38163507 Free article.

4

Identification, biological evaluation, and crystallographic analysis of coumestrol as a novel dual-specificity tyrosine-phosphorylation-regulated kinase 1A inhibitor.

Peng CH, Hwang TL, Hung SC, Tu HJ, Tseng YT, Lin TE, Lee CC, Tseng YC, Ko CY, Yen SC, Hsu KC, Pan SL, HuangFu WC. Peng CH, et al. Among authors: tu hj. Int J Biol Macromol. 2024 Dec;282(Pt 4):136860. doi: 10.1016/j.ijbiomac.2024.136860. Epub 2024 Oct 29. Int J Biol Macromol. 2024. PMID: 39481728 Free article.

5

Discovering a novel dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and its impact on tau phosphorylation and amyloid-β formation.

Tu HJ, Chao MW, Lee CC, Peng CS, Wu YW, Lin TE, Chang YW, Yen SC, Hsu KC, Pan SL, HuangFu WC. Tu HJ, et al. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2418470. doi: 10.1080/14756366.2024.2418470. Epub 2024 Nov 4. J Enzyme Inhib Med Chem. 2024. PMID: 39494990 Free PMC article.

6

A Novel Selective JAK2 Inhibitor Identified Using Pharmacological Interactions.

Lin TE, HuangFu WC, Chao MW, Sung TY, Chang CD, Chen YY, Hsieh JH, Tu HJ, Huang HL, Pan SL, Hsu KC. Lin TE, et al. Among authors: tu hj. Front Pharmacol. 2018 Dec 4;9:1379. doi: 10.3389/fphar.2018.01379. eCollection 2018. Front Pharmacol. 2018. PMID: 30564118 Free PMC article.

7

Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach.

Chao MW, Lin TE, HuangFu WC, Chang CD, Tu HJ, Chen LC, Yen SC, Sung TY, Huang WJ, Yang CR, Pan SL, Hsu KC. Chao MW, et al. Among authors: tu hj. J Enzyme Inhib Med Chem. 2021 Dec;36(1):98-108. doi: 10.1080/14756366.2020.1843452. J Enzyme Inhib Med Chem. 2021. PMID: 33167727 Free PMC article.

8

A novel dual HDAC and HSP90 inhibitor, MPT0G449, downregulates oncogenic pathways in human acute leukemia in vitro and in vivo.

Wu YW, Chao MW, Tu HJ, Chen LC, Hsu KC, Liou JP, Yang CR, Yen SC, HuangFu WC, Pan SL. Wu YW, et al. Among authors: tu hj. Oncogenesis. 2021 May 13;10(5):39. doi: 10.1038/s41389-021-00331-0. Oncogenesis. 2021. PMID: 33986242 Free PMC article.

9

O-methylated flavonol as a multi-kinase inhibitor of leukemogenic kinases exhibits a potential treatment for acute myeloid leukemia.

Yen SC, Wu YW, Huang CC, Chao MW, Tu HJ, Chen LC, Lin TE, Sung TY, Tseng HJ, Chu JC, Huang WJ, Yang CR, HuangFu WC, Pan SL, Hsu KC. Yen SC, et al. Among authors: tu hj. Phytomedicine. 2022 Jun;100:154061. doi: 10.1016/j.phymed.2022.154061. Epub 2022 Mar 16. Phytomedicine. 2022. PMID: 35364561 Free article.

10

In silico identification and biological evaluation of a selective MAP4K4 inhibitor against pancreatic cancer.

Chang CD, Chao MW, Lee HY, Liu YT, Tu HJ, Lien ST, Lin TE, Sung TY, Yen SC, Huang SH, Hsu KC, Pan SL. Chang CD, et al. Among authors: tu hj. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2166039. doi: 10.1080/14756366.2023.2166039. J Enzyme Inhib Med Chem. 2023. PMID: 36683274 Free PMC article.

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