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Bisphenol A single and repeated treatment increases HDAC2, leading to cholinergic neurotransmission dysfunction and SN56 cholinergic apoptotic cell death through AChE variants overexpression and NGF/TrkA/P75NTR signaling disruption.
Moyano P, Flores A, García J, García JM, Anadon MJ, Frejo MT, Sola E, Pelayo A, Del Pino J. Moyano P, et al. Among authors: garcia jm, garcia j. Food Chem Toxicol. 2021 Nov;157:112614. doi: 10.1016/j.fct.2021.112614. Epub 2021 Oct 14. Food Chem Toxicol. 2021. PMID: 34655688
Insulin Signaling Disruption and INF-γ Upregulation Induce Aβ1-42 and Hyperphosphorylated-Tau Proteins Synthesis and Cell Death after Paraquat Treatment of Primary Hippocampal Cells.
Abascal ML, Sanjuan J, Moyano P, Sola E, Flores A, Garcia JM, Garcia J, Frejo MT, Del Pino J. Abascal ML, et al. Among authors: garcia jm, garcia j. Chem Res Toxicol. 2022 Dec 19;35(12):2214-2218. doi: 10.1021/acs.chemrestox.2c00278. Epub 2022 Nov 17. Chem Res Toxicol. 2022. PMID: 36394833 Free PMC article.
Cadmium-promoted thyroid hormones disruption mediates ROS, inflammation, Aβ and Tau proteins production, gliosis, spongiosis and neurodegeneration in rat basal forebrain.
Sola E, Moyano P, Flores A, García JM, García J, Anadon MJ, Frejo MT, Pelayo A, de la Cabeza Fernandez M, Del Pino J. Sola E, et al. Among authors: garcia jm, garcia j. Chem Biol Interact. 2023 Apr 25;375:110428. doi: 10.1016/j.cbi.2023.110428. Epub 2023 Mar 1. Chem Biol Interact. 2023. PMID: 36868496 Free article.
SN56 basal forebrain cholinergic neuronal loss after acute and long-term chlorpyrifos exposure through oxidative stress generation; P75(NTR) and α7-nAChRs alterations mediated partially by AChE variants disruption.
Del Pino J, Moyano P, Anadon MJ, García JM, Díaz MJ, Gómez G, García J, Frejo MT. Del Pino J, et al. Among authors: garcia jm, garcia j. Toxicology. 2016 Apr 15;353-354:48-57. doi: 10.1016/j.tox.2016.05.007. Epub 2016 May 6. Toxicology. 2016. PMID: 27163631
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