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Multi-stage-mixing to create a core-then-shell structure improves DNA-loaded lipid nanoparticles' transfection by orders of magnitude.
Nong J, Gong X, Dang QM, Tiwari S, Patel M, Wu J, Hanna A, Park WJ, Atochina-Vasserman EN, Huang HT, Marcos-Contreras OA, Morris-Blanco KC, Miner JJ, Weissman D, Muzykantov VR, Gupta K, Issadore D, Myerson JW, Wang Z, Brenner JS. Nong J, et al. Among authors: weissman d. bioRxiv [Preprint]. 2024 Nov 15:2024.11.12.623321. doi: 10.1101/2024.11.12.623321. bioRxiv. 2024. PMID: 39605450 Free PMC article. Preprint.
Targeted delivery of TGF-β mRNA to lung parenchyma using one-component ionizable amphiphilic Janus Dendrimers.
Atochina-Vasserman E, Meshanni J, Stevenson E, Zhang D, Sun R, Ona N, Reagan E, Abramova E, Guo CJ, Wilkinson M, Baboo I, Yang Y, Pan L, Maurya D, Percec V, Li Y, Gow A, Weissman D. Atochina-Vasserman E, et al. Among authors: weissman d. Res Sq [Preprint]. 2024 Jul 12:rs.3.rs-4656663. doi: 10.21203/rs.3.rs-4656663/v1. Res Sq. 2024. PMID: 39041040 Free PMC article. Preprint.
Multiarm-Assisted Design of Dendron-like Degradable Ionizable Lipids Facilitates Systemic mRNA Delivery to the Spleen.
Xue L, Xiong X, Zhao G, Molina-Arocho W, Palanki R, Xiao Z, Han X, Yoon IC, Figueroa-Espada CG, Xu J, Gong N, Shi Q, Chen Q, Alameh MG, Vaughan AE, Haldar M, Wang K, Weissman D, Mitchell MJ. Xue L, et al. Among authors: weissman d. J Am Chem Soc. 2025 Jan 15;147(2):1542-1552. doi: 10.1021/jacs.4c10265. Epub 2025 Jan 1. J Am Chem Soc. 2025. PMID: 39742515
Toward a Complete Elucidation of the Primary Structure-Activity in Pentaerythritol-Based One-Component Ionizable Amphiphilic Janus Dendrimers for In Vivo Delivery of Luc-mRNA.
Sahoo D, Atochina-Vasserman EN, Lu J, Maurya DS, Ona N, Vasserman JA, Ni H, Berkihiser S, Park WJ, Weissman D, Percec V. Sahoo D, et al. Among authors: weissman d. Biomacromolecules. 2025 Jan 13;26(1):726-737. doi: 10.1021/acs.biomac.4c01599. Epub 2024 Dec 17. Biomacromolecules. 2025. PMID: 39688403
Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia.
Swingle KL, Hamilton AG, Safford HC, Geisler HC, Thatte AS, Palanki R, Murray AM, Han EL, Mukalel AJ, Han X, Joseph RA, Ghalsasi AA, Alameh MG, Weissman D, Mitchell MJ. Swingle KL, et al. Among authors: weissman d. Nature. 2025 Jan;637(8045):412-421. doi: 10.1038/s41586-024-08291-2. Epub 2024 Dec 11. Nature. 2025. PMID: 39663452
839 results