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Page 1
A Covalent Chemical Probe for Chikungunya nsP2 Cysteine Protease with Antialphaviral Activity and Proteome-wide Selectivity.
Ghoshal A, Tse EG, Hossain MA, Asressu KH, Merten EM, Sears JD, Howell S, Perveen S, Burdick J, Morales NL, Martinez SA, Law I, Davenport BJ, Morrison TE, Streblow ZJ, Streblow DN, Mordant AL, Webb TS, Cabrera A, Herring LE, Arrowsmith CH, Pearce KH, Moorman NJ, Heise MT, Couñago RM, Brown PJ, Willson TM. Ghoshal A, et al. Among authors: merten em. Res Sq [Preprint]. 2024 Nov 12:rs.3.rs-5363451. doi: 10.21203/rs.3.rs-5363451/v1. Res Sq. 2024. PMID: 39606462 Free PMC article. Preprint.
Discovery of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach.
Merten EM, Sears JD, Leisner TM, Hardy PB, Ghoshal A, Hossain MA, Asressu KH, Brown PJ, Stashko MA, Herring L, Mordant AL, Webb TS, Mills CA, Barker NK, Streblow ZJ, Perveen S, Arrowsmith C, Arnold JJ, Cameron CE, Streblow DN, Moorman NJ, Heise M, Willson TM, Popov K, Pearce KH. Merten EM, et al. bioRxiv [Preprint]. 2024 May 23:2024.03.22.586341. doi: 10.1101/2024.03.22.586341. bioRxiv. 2024. Update in: Proc Natl Acad Sci U S A. 2024 Oct 15;121(42):e2409166121. doi: 10.1073/pnas.2409166121 PMID: 38562906 Free PMC article. Updated. Preprint.
Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of Chikungunya nsP2 Cysteine Protease with Anti-alphavirus Activity.
Ghoshal A, Asressu KH, Hossain MA, Brown PJ, Merten EM, Sears JD, Perveen S, Pearce KH, Popov KI, Moorman NJ, Heise MT, Willson TM. Ghoshal A, et al. Among authors: merten em. bioRxiv [Preprint]. 2024 Jun 13:2024.06.12.598722. doi: 10.1101/2024.06.12.598722. bioRxiv. 2024. Update in: J Med Chem. 2024 Sep 26;67(18):16505-16532. doi: 10.1021/acs.jmedchem.4c01346 PMID: 38915519 Free PMC article. Updated. Preprint.
Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of Chikungunya nsP2 Cysteine Protease with Antialphavirus Activity.
Ghoshal A, Asressu KH, Hossain MA, Brown PJ, Nandakumar M, Vala A, Merten EM, Sears JD, Law I, Burdick JE, Morales NL, Perveen S, Pearce KH, Popov KI, Moorman NJ, Heise MT, Willson TM. Ghoshal A, et al. Among authors: merten em. J Med Chem. 2024 Sep 26;67(18):16505-16532. doi: 10.1021/acs.jmedchem.4c01346. Epub 2024 Sep 5. J Med Chem. 2024. PMID: 39235978 Free PMC article.
Identification of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach.
Merten EM, Sears JD, Leisner TM, Hardy PB, Ghoshal A, Hossain MA, Asressu KH, Brown PJ, Tse EG, Stashko MA, Li K, Norris-Drouin JL, Herring LE, Mordant AL, Webb TS, Mills CA, Barker NK, Streblow ZJ, Perveen S, Arrowsmith CH, Couñago RM, Arnold JJ, Cameron CE, Streblow DN, Moorman NJ, Heise MT, Willson TM, Popov KI, Pearce KH. Merten EM, et al. Proc Natl Acad Sci U S A. 2024 Oct 15;121(42):e2409166121. doi: 10.1073/pnas.2409166121. Epub 2024 Oct 10. Proc Natl Acad Sci U S A. 2024. PMID: 39388272
Identification of Inhibitors of Chikungunya virus nsP2 ATPase.
Navarro H, Scott JE, Smith GR, Ghiabi P, Gibson E, Loppnau P, Harding RJ, Hossain MA, Bose MR, Pearce KH, Merten EM, Willson TM, Brown PJ. Navarro H, et al. Among authors: merten em. bioRxiv [Preprint]. 2024 Dec 6:2024.12.02.625520. doi: 10.1101/2024.12.02.625520. bioRxiv. 2024. PMID: 39677726 Free PMC article. Preprint.
Computational and Experimental Approaches Identify Beta-Blockers as Potential SARS-CoV-2 Spike Inhibitors.
Puhl AC, Mottin M, Sacramento CQ, Tavella TA, Dias GG, Fintelman-Rodrigues N, Temerozo JR, Dias SSG, Ramos PRPDS, Merten EM, Pearce KH, Costa FTM, Premkumar L, Souza TML, Andrade CH, Ekins S. Puhl AC, et al. Among authors: merten em. ACS Omega. 2022 Aug 8;7(32):27950-27958. doi: 10.1021/acsomega.2c01707. eCollection 2022 Aug 16. ACS Omega. 2022. PMID: 35983371 Free PMC article.