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The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk.
Valdecantos MP, Ruiz L, Folgueira C, Rada P, Gomez-Santos B, Solas M, Hitos AB, Field J, Francisco V, Escalona-Garrido C, Zagmutt S, Calderon-Dominguez M, Mera P, Garcia-Martinez I, Maymó-Masip E, Grajales D, Alen R, Mora A, Sáinz N, Vides-Urrestarazu I, Vilarrasa N, Arbones-Mainar JM, Zaragoza C, Moreno-Aliaga MJ, Aspichueta P, Fernández-Veledo S, Vendrell J, Serra D, Herrero L, Schreiber R, Zechner R, Sabio G, Hornigold D, Rondinone CM, Jermutus L, Grimsby J, Valverde ÁM. Valdecantos MP, et al. Among authors: vendrell j. Nat Commun. 2024 Nov 28;15(1):10342. doi: 10.1038/s41467-024-54080-w. Nat Commun. 2024. PMID: 39609390 Free PMC article.
Role of adipose tissue GLP-1R expression in metabolic improvement after bariatric surgery in patients with type 2 diabetes.
Ejarque M, Guerrero-Pérez F, de la Morena N, Casajoana A, Virgili N, López-Urdiales R, Maymó-Masip E, Pujol Gebelli J, Garcia Ruiz de Gordejuela A, Perez-Maraver M, Pellitero S, Fernández-Veledo S, Vendrell J, Vilarrasa N. Ejarque M, et al. Among authors: vendrell j. Sci Rep. 2019 Apr 18;9(1):6274. doi: 10.1038/s41598-019-42770-1. Sci Rep. 2019. PMID: 31000783 Free PMC article. Clinical Trial.
The rise of soluble TWEAK levels in severely obese subjects after bariatric surgery may affect adipocyte-cytokine production induced by TNFα.
Maymó-Masip E, Fernández-Veledo S, Garcia España A, Vázquez-Carballo A, Tinahones FJ, García-Fuentes E, Garrifo-Sanchez L, Rodriguez Mdel M, Vendrell J, Chacón MR. Maymó-Masip E, et al. Among authors: vendrell j. J Clin Endocrinol Metab. 2013 Aug;98(8):E1323-33. doi: 10.1210/jc.2012-4177. Epub 2013 Jun 19. J Clin Endocrinol Metab. 2013. PMID: 23783093 Free article.
SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity.
Keiran N, Ceperuelo-Mallafré V, Calvo E, Hernández-Alvarez MI, Ejarque M, Núñez-Roa C, Horrillo D, Maymó-Masip E, Rodríguez MM, Fradera R, de la Rosa JV, Jorba R, Megia A, Zorzano A, Medina-Gómez G, Serena C, Castrillo A, Vendrell J, Fernández-Veledo S. Keiran N, et al. Among authors: vendrell j. Nat Immunol. 2019 May;20(5):581-592. doi: 10.1038/s41590-019-0372-7. Epub 2019 Apr 8. Nat Immunol. 2019. PMID: 30962591 Free article.
Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function.
Ejarque M, Sabadell-Basallote J, Beiroa D, Calvo E, Keiran N, Nuñez-Roa C, Rodríguez MDM, Sabench F, Del Castillo D, Jimenez V, Bosch F, Nogueiras R, Vendrell J, Fernández-Veledo S. Ejarque M, et al. Among authors: vendrell j. Br J Pharmacol. 2021 May;178(10):2131-2145. doi: 10.1111/bph.15278. Epub 2020 Nov 19. Br J Pharmacol. 2021. PMID: 32986861 Free article.
Effects of stem cells from inducible brown adipose tissue on diet-induced obesity in mice.
Calvo E, Keiran N, Núñez-Roa C, Maymó-Masip E, Ejarque M, Sabadell-Basallote J, Del Mar Rodríguez-Peña M, Ceperuelo-Mallafré V, Seco J, Benaiges E, Michalopoulou T, Jorba R, Vendrell J, Fernández-Veledo S. Calvo E, et al. Among authors: vendrell j. Sci Rep. 2021 Jul 6;11(1):13923. doi: 10.1038/s41598-021-93224-6. Sci Rep. 2021. PMID: 34230537 Free PMC article.
585 results