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Characterizing the pharmacological interaction of the antimalarial combination artefenomel-piperaquine in healthy volunteers with induced blood-stage Plasmodium falciparum to predict efficacy in patients with malaria.
Abd-Rahman AN, Kaschek D, Kümmel A, Webster R, Potter AJ, Odedra A, Woolley SD, Llewellyn S, Webb L, Marquart L, Chalon S, Gaaloul ME, McCarthy JS, Möhrle JJ, Barber BE. Abd-Rahman AN, et al. Among authors: chalon s. BMC Med. 2024 Nov 28;22(1):563. doi: 10.1186/s12916-024-03787-0. BMC Med. 2024. PMID: 39609822 Free PMC article. Clinical Trial.
Longitudinal changes in iron homeostasis in human experimental and clinical malaria.
Woolley SD, Grigg MJ, Marquart L, Gower J, Piera K, Nair AS, Amante FM, Rajahram GS, William T, Frazer DM, Chalon S, McCarthy JS, Anstey NM, Barber BE. Woolley SD, et al. Among authors: chalon s. medRxiv [Preprint]. 2023 Dec 21:2023.12.19.23300265. doi: 10.1101/2023.12.19.23300265. medRxiv. 2023. Update in: EBioMedicine. 2024 Jul;105:105189. doi: 10.1016/j.ebiom.2024.105189 PMID: 38196596 Free PMC article. Updated. Preprint.
Characterising the blood-stage antimalarial activity of pyronaridine in healthy volunteers experimentally infected with Plasmodium falciparum.
Barber BE, Webster R, Potter AJ, Llewellyn S, Sahai N, Leelasena I, Mathison S, Kuritz K, Flynn J, Chalon S, Marrast AC, Gobeau N, Moehrle JJ. Barber BE, et al. Among authors: chalon s. Int J Antimicrob Agents. 2024 Jul;64(1):107196. doi: 10.1016/j.ijantimicag.2024.107196. Epub 2024 May 10. Int J Antimicrob Agents. 2024. PMID: 38734217 Free article.
Longitudinal changes in iron homeostasis in human experimental and clinical malaria.
Woolley SD, Grigg MJ, Marquart L, Gower JSE, Piera K, Nair AS, Amante FM, Rajahram GS, William T, Frazer DM, Chalon S, McCarthy JS, Anstey NM, Barber BE. Woolley SD, et al. Among authors: chalon s. EBioMedicine. 2024 Jul;105:105189. doi: 10.1016/j.ebiom.2024.105189. Epub 2024 Jun 7. EBioMedicine. 2024. PMID: 38851058 Free PMC article.
Safety, tolerability, pharmacokinetics, and antimalarial activity of MMV533: a phase 1a first-in-human, randomised, ascending dose and food effect study, and a phase 1b Plasmodium falciparum volunteer infection study.
Bestgen B, Jones S, Thathy V, Kuemmerle A, Barcelo C, Haouala A, Gossen D, Marx MW, Di Resta I, Szramowska M, Webster RA, Llewellyn S, Ritacco DA, Yeo T, Leroy D, Barber BE, Fidock DA, Griffin P, Lickliter J, Chalon S. Bestgen B, et al. Among authors: chalon s. Lancet Infect Dis. 2024 Dec 18:S1473-3099(24)00664-9. doi: 10.1016/S1473-3099(24)00664-9. Online ahead of print. Lancet Infect Dis. 2024. PMID: 39708824 Free article.
DESI-TQ-MS imaging for ex vivo brain biodistribution assessment: evaluation of LBT-999, a ligand of the dopamine transporter (DAT).
Galineau L, Claude E, Gulhan Z, Bodard S, Sérrière S, Dupuy C, Monteiro J, Oury A, Bertevello P, Chicheri G, Vercouillie J, Nadal-Desbarats L, Chalon S, Lefèvre A, Emond P. Galineau L, et al. Among authors: chalon s. EJNMMI Radiopharm Chem. 2024 Aug 27;9(1):63. doi: 10.1186/s41181-024-00289-5. EJNMMI Radiopharm Chem. 2024. PMID: 39192050 Free PMC article.
A randomized, open-label two-period crossover pilot study to evaluate the relative bioavailability in the fed state of atovaquone-proguanil (Atoguanil™) versus atovaquone-proguanil hydrochloride (Malarone®) in healthy adult participants.
Kuemmerle A, Gossen D, Marx MW, Lorch U, Szramowska M, Kumar A, Singh D, Singh S, Ramachandruni H, Thankachen B, Kore S, Gaaloul ME, Borghini-Fuhrer I, Chalon S. Kuemmerle A, et al. Among authors: chalon s. Naunyn Schmiedebergs Arch Pharmacol. 2024 Dec;397(12):9823-9832. doi: 10.1007/s00210-024-03245-x. Epub 2024 Jun 25. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 38918235 Free PMC article. Clinical Trial.
Glutamatergic synapse in autism: a complex story for a complex disorder.
Galineau L, Arlicot N, Dupont AC, Briend F, Houy-Durand E, Tauber C, Gomot M, Gissot V, Barantin L, Lefevre A, Vercouillie J, Roussel C, Roux S, Nadal L, Mavel S, Laumonnier F, Belzung C, Chalon S, Emond P, Santiago-Ribeiro MJ, Bonnet-Brilhault F. Galineau L, et al. Among authors: chalon s. Mol Psychiatry. 2023 Feb;28(2):801-809. doi: 10.1038/s41380-022-01860-9. Epub 2022 Nov 25. Mol Psychiatry. 2023. PMID: 36434055
241 results