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Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson's disease.
Barekatain M, Johansson LC, Lam JH, Chang H, Sadybekov AV, Han GW, Russo J, Bliesath J, Brice NL, Carlton MBL, Saikatendu KS, Sun H, Murphy ST, Monenschein H, Schiffer HH, Popov P, Lutomski CA, Robinson CV, Liu ZJ, Hua T, Katritch V, Cherezov V. Barekatain M, et al. Among authors: hua t. Sci Signal. 2024 Dec 3;17(865):eado8741. doi: 10.1126/scisignal.ado8741. Epub 2024 Dec 3. Sci Signal. 2024. PMID: 39626010
Structural features of activated GPCR signaling complexes.
Wang J, Hua T, Liu ZJ. Wang J, et al. Among authors: hua t. Curr Opin Struct Biol. 2020 Aug;63:82-89. doi: 10.1016/j.sbi.2020.04.008. Epub 2020 May 30. Curr Opin Struct Biol. 2020. PMID: 32485565 Review.
Crystal Structure of the Human Cannabinoid Receptor CB2.
Li X, Hua T, Vemuri K, Ho JH, Wu Y, Wu L, Popov P, Benchama O, Zvonok N, Locke K, Qu L, Han GW, Iyer MR, Cinar R, Coffey NJ, Wang J, Wu M, Katritch V, Zhao S, Kunos G, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ. Li X, et al. Among authors: hua t. Cell. 2019 Jan 24;176(3):459-467.e13. doi: 10.1016/j.cell.2018.12.011. Epub 2019 Jan 10. Cell. 2019. PMID: 30639103 Free PMC article.
Heterologous Expression and Purification of GPCRs.
Li X, Shen L, Liu J, Liu X, Liu ZJ, Hua T. Li X, et al. Among authors: hua t. Methods Mol Biol. 2022;2507:295-312. doi: 10.1007/978-1-0716-2368-8_15. Methods Mol Biol. 2022. PMID: 35773588
Crystal structures of agonist-bound human cannabinoid receptor CB1.
Hua T, Vemuri K, Nikas SP, Laprairie RB, Wu Y, Qu L, Pu M, Korde A, Jiang S, Ho JH, Han GW, Ding K, Li X, Liu H, Hanson MA, Zhao S, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ. Hua T, et al. Nature. 2017 Jul 27;547(7664):468-471. doi: 10.1038/nature23272. Epub 2017 Jul 5. Nature. 2017. PMID: 28678776 Free PMC article.
716 results