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Page 1
The GIP receptor activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive weight loss in mice.
Yu X, Chen S, Funcke JB, Straub LG, Pirro V, Emont MP, Droz BA, Collins KA, Joung C, Pearson MJ, James CM, Babu GJ, Efthymiou V, Vernon A, Patti ME, An YA, Rosen ED, Coghlan MP, Samms RJ, Scherer PE, Kusminski CM. Yu X, et al. Among authors: scherer pe. Cell Metab. 2025 Jan 7;37(1):187-204.e7. doi: 10.1016/j.cmet.2024.11.003. Epub 2024 Dec 5. Cell Metab. 2025. PMID: 39642881
Protective roles of adiponectin and molecular signatures of HNF4α and PPARα as downstream targets of adiponectin in pancreatic β cells.
Onodera T, Kim DS, Ye R, Wang MY, Chen S, Field BC, Straub L, Sun XN, Li C, Lee C, Paredes M, Crewe C, Zhao S, Kusminski CM, Gordillo R, Scherer PE. Onodera T, et al. Among authors: scherer pe. Mol Metab. 2023 Dec;78:101821. doi: 10.1016/j.molmet.2023.101821. Epub 2023 Oct 6. Mol Metab. 2023. PMID: 37806486 Free PMC article.
GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice.
Furber EC, Hyatt K, Collins K, Yu X, Droz BA, Holland A, Friedrich JL, Wojnicki S, Konkol DL, O'Farrell LS, Baker HE, Coskun T, Scherer PE, Kusminski CM, Christe ME, Sloop KW, Samms RJ. Furber EC, et al. Among authors: scherer pe. Diabetes. 2024 Feb 1;73(2):292-305. doi: 10.2337/db23-0172. Diabetes. 2024. PMID: 37934926 Free PMC article.
Transforming obesity: The advancement of multi-receptor drugs.
Kusminski CM, Perez-Tilve D, Müller TD, DiMarchi RD, Tschöp MH, Scherer PE. Kusminski CM, et al. Among authors: scherer pe. Cell. 2024 Jul 25;187(15):3829-3853. doi: 10.1016/j.cell.2024.06.003. Cell. 2024. PMID: 39059360 Review.
Leptin Reduction as a Required Component for Weight Loss.
Zhao S, Li N, Xiong W, Li G, He S, Zhang Z, Zhu Q, Jiang N, Ikejiofor C, Zhu Y, Wang MY, Han X, Zhang N, Solis-Herrera C, Kusminski C, An Z, Elmquist JK, Scherer PE. Zhao S, et al. Among authors: scherer pe. Diabetes. 2024 Feb 1;73(2):197-210. doi: 10.2337/db23-0571. Diabetes. 2024. PMID: 37935033
Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease.
Wang MY, Zhang Z, Zhao S, Onodera T, Sun XN, Zhu Q, Li C, Li N, Chen S, Paredes M, Gautron L, Charron MJ, Marciano DK, Gordillo R, Drucker DJ, Scherer PE. Wang MY, et al. Among authors: scherer pe. Cell Metab. 2024 Mar 5;36(3):575-597.e7. doi: 10.1016/j.cmet.2023.12.024. Epub 2024 Jan 17. Cell Metab. 2024. PMID: 38237602
Update on Adipose Tissue and Cancer.
Brown KA, Scherer PE. Brown KA, et al. Among authors: scherer pe. Endocr Rev. 2023 Nov 9;44(6):961-974. doi: 10.1210/endrev/bnad015. Endocr Rev. 2023. PMID: 37260403 Free PMC article.
527 results