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Page 1
Preclinical safety and efficacy of the recombinant CR1 drug product CSL040 in rats and cynomolgus monkeys.
Ruthsatz T, Wymann S, Velkoska E, Mansour M, Schu D, Lichtfuss M, Rossato P, FitzPatrick M, Hosback S, Dyson A, Herzog E, Martin K, Dietrich B, Hardy MP. Ruthsatz T, et al. Among authors: hardy mp. Toxicol Appl Pharmacol. 2024 Dec 6;495:117191. doi: 10.1016/j.taap.2024.117191. Online ahead of print. Toxicol Appl Pharmacol. 2024. PMID: 39647511 Free article.
Sialylation-dependent pharmacokinetics and differential complement pathway inhibition are hallmarks of CR1 activity in vivo.
Wymann S, Mischnik M, Leong D, Ghosh S, Tan X, Cao H, Kuehnemuth B, Powers GA, Halder P, de Souza MJ, James HS, Tomasetig V, Lind H, Rossato P, Owczarek CM, Ow SY, Dower SK, Baz Morelli A, Rowe T, Hardy MP. Wymann S, et al. Among authors: hardy mp. Biochem J. 2022 May 13;479(9):1007-1030. doi: 10.1042/BCJ20220054. Biochem J. 2022. PMID: 35470373
A novel soluble complement receptor 1 fragment with enhanced therapeutic potential.
Wymann S, Dai Y, Nair AG, Cao H, Powers GA, Schnell A, Martin-Roussety G, Leong D, Simmonds J, Lieu KG, de Souza MJ, Mischnik M, Taylor S, Ow SY, Spycher M, Butcher RE, Pearse M, Zuercher AW, Baz Morelli A, Panousis C, Wilson MJ, Rowe T, Hardy MP. Wymann S, et al. Among authors: hardy mp. J Biol Chem. 2021 Jan-Jun;296:100200. doi: 10.1074/jbc.RA120.016127. Epub 2020 Dec 23. J Biol Chem. 2021. PMID: 33334893 Free PMC article.
Increased potency of recombinant VWF D'D3 albumin fusion proteins engineered for enhanced affinity for coagulation factor VIII.
Chia J, Pestel S, Glauser I, Emmrich K, Hardy MP, Mischnik M, Raquet E, Tomasetig V, Claar P, Zalewski A, Bass GT, Turnbull V, Chen CG, Wilson MJ, Panousis C, Weimer T, Andrews A, Verhagen AM, Dower SK. Chia J, et al. Among authors: hardy mp. J Thromb Haemost. 2021 Nov;19(11):2710-2725. doi: 10.1111/jth.15480. Epub 2021 Aug 17. J Thromb Haemost. 2021. PMID: 34333849 Free article.
Modular Platform for the Development of Recombinant Hemoglobin Scavenger Biotherapeutics.
Buzzi RM, Owczarek CM, Akeret K, Tester A, Pereira N, Butcher R, Brügger-Verdon V, Hardy MP, Illi M, Wassmer A, Vallelian F, Humar R, Hugelshofer M, Buehler PW, Gentinetta T, Schaer DJ. Buzzi RM, et al. Among authors: hardy mp. Mol Pharm. 2021 Aug 2;18(8):3158-3170. doi: 10.1021/acs.molpharmaceut.1c00433. Epub 2021 Jul 22. Mol Pharm. 2021. PMID: 34292741 Free article.
178 results