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Direct ionic stress sensing and mitigation by the transcription factor NFAT5.
Khandwala CB, Sarkar P, Schmidt HB, Ma M, Kinnebrew M, Pusapati GV, Patel BB, Tillo D, Lebensohn AM, Rohatgi R. Khandwala CB, et al. Among authors: rohatgi r. bioRxiv [Preprint]. 2023 Sep 24:2023.09.23.559074. doi: 10.1101/2023.09.23.559074. bioRxiv. 2023. PMID: 37886503 Free PMC article. Preprint.
Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain.
Kinnebrew M, Woolley RE, Ansell TB, Byrne EFX, Frigui S, Luchetti G, Sircar R, Nachtergaele S, Mydock-McGrane L, Krishnan K, Newstead S, Sansom MSP, Covey DF, Siebold C, Rohatgi R. Kinnebrew M, et al. Among authors: rohatgi r. Sci Adv. 2022 Jun 3;8(22):eabm5563. doi: 10.1126/sciadv.abm5563. Epub 2022 Jun 3. Sci Adv. 2022. PMID: 35658032 Free PMC article.
Cholesterol accessibility at the ciliary membrane controls hedgehog signaling.
Kinnebrew M, Iverson EJ, Patel BB, Pusapati GV, Kong JH, Johnson KA, Luchetti G, Eckert KM, McDonald JG, Covey DF, Siebold C, Radhakrishnan A, Rohatgi R. Kinnebrew M, et al. Among authors: rohatgi r. Elife. 2019 Oct 30;8:e50051. doi: 10.7554/eLife.50051. Elife. 2019. PMID: 31657721 Free PMC article.
The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Rudolf AF, Kinnebrew M, Kowatsch C, Ansell TB, El Omari K, Bishop B, Pardon E, Schwab RA, Malinauskas T, Qian M, Duman R, Covey DF, Steyaert J, Wagner A, Sansom MSP, Rohatgi R, Siebold C. Rudolf AF, et al. Among authors: rohatgi r. Nat Chem Biol. 2019 Oct;15(10):975-982. doi: 10.1038/s41589-019-0370-y. Epub 2019 Sep 23. Nat Chem Biol. 2019. PMID: 31548691 Free PMC article.
167 results