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Blood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects.
Blömeke L, Rehn F, Pils M, Kraemer-Schulien V, Cousin A, Kutzsche J, Bujnicki T, Freiesleben SD, Schneider LS, Preis L, Priller J, Spruth EJ, Altenstein S, Schneider A, Fliessbach K, Wiltfang J, Hansen N, Rostamzadeh A, Düzel E, Glanz W, Incesoy EI, Buerger K, Janowitz D, Ewers M, Perneczky R, Rauchmann BS, Teipel S, Kilimann I, Laske C, Munk MH, Spottke A, Roy N, Heneka MT, Brosseron F, Wagner M, Roeske S, Ramirez A, Schmid M, Jessen F, Bannach O, Peters O, Willbold D. Blömeke L, et al. Among authors: kutzsche j. Commun Med (Lond). 2024 Dec 10;4(1):262. doi: 10.1038/s43856-024-00690-w. Commun Med (Lond). 2024. PMID: 39658587 Free PMC article.
Elevated Aβ aggregates in feces from Alzheimer's disease patients: a proof-of-concept study.
Pils M, Dybala A, Schaffrath A, Rehn F, Kutzsche J, Blömeke L, Tusche M, Özdüzenciler P, Bujnicki T, Kraemer-Schulien V, Gramespacher H, Schmieschek MHT, Barbe MT, Onur OA, Fink GR, Tamgüney G, Bannach O, Willbold D. Pils M, et al. Among authors: kutzsche j. Alzheimers Res Ther. 2024 Oct 14;16(1):223. doi: 10.1186/s13195-024-01597-3. Alzheimers Res Ther. 2024. PMID: 39402637 Free PMC article.
Aβ oligomers peak in early stages of Alzheimer's disease preceding tau pathology.
Blömeke L, Rehn F, Kraemer-Schulien V, Kutzsche J, Pils M, Bujnicki T, Lewczuk P, Kornhuber J, Freiesleben SD, Schneider LS, Preis L, Priller J, Spruth EJ, Altenstein S, Lohse A, Schneider A, Fliessbach K, Wiltfang J, Hansen N, Rostamzadeh A, Düzel E, Glanz W, Incesoy EI, Butryn M, Buerger K, Janowitz D, Ewers M, Perneczky R, Rauchmann BS, Teipel S, Kilimann I, Goerss D, Laske C, Munk MH, Sanzenbacher C, Spottke A, Roy-Kluth N, Heneka MT, Brosseron F, Wagner M, Wolfsgruber S, Kleineidam L, Stark M, Schmid M, Jessen F, Bannach O, Willbold D, Peters O. Blömeke L, et al. Among authors: kutzsche j. Alzheimers Dement (Amst). 2024 Apr 25;16(2):e12589. doi: 10.1002/dad2.12589. eCollection 2024 Apr-Jun. Alzheimers Dement (Amst). 2024. PMID: 38666085 Free PMC article.
Oral treatment with the all-d-peptide RD2 enhances cognition in aged beagle dogs - A model of sporadic Alzheimer's disease.
Kutzsche J, Schemmert S, Bujnicki T, Zafiu C, Halbgebauer S, Kraemer-Schulien V, Pils M, Blömeke L, Post J, Kulawik A, Jürgens D, Rossberg WM, Hümpel M, Bannach O, Otto M, Araujo JA, Willuweit A, Willbold D. Kutzsche J, et al. Heliyon. 2023 Jul 29;9(8):e18443. doi: 10.1016/j.heliyon.2023.e18443. eCollection 2023 Aug. Heliyon. 2023. PMID: 37609390 Free PMC article.
All-d-Enantiomeric Peptide D3 Designed for Alzheimer's Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-β Precursors.
Bocharov EV, Gremer L, Urban AS, Okhrimenko IS, Volynsky PE, Nadezhdin KD, Bocharova OV, Kornilov DA, Zagryadskaya YA, Kamynina AV, Kuzmichev PK, Kutzsche J, Bolakhrif N, Müller-Schiffmann A, Dencher NA, Arseniev AS, Efremov RG, Gordeliy VI, Willbold D. Bocharov EV, et al. Among authors: kutzsche j. J Med Chem. 2021 Nov 25;64(22):16464-16479. doi: 10.1021/acs.jmedchem.1c00632. Epub 2021 Nov 5. J Med Chem. 2021. PMID: 34739758
43 results