Westover KD - Search Results

1

SRC kinase drives multidrug resistance induced by KRAS-G12C inhibition.

Song X, Zhou Z, Elmezayen A, Wu R, Yu C, Gao B, Minna JD, Westover KD, Zeh HJ, Kroemer G, Heasley LE, Kang R, Tang D. Song X, et al. Among authors: westover kd. Sci Adv. 2024 Dec 13;10(50):eadq4274. doi: 10.1126/sciadv.adq4274. Epub 2024 Dec 11. Sci Adv. 2024. PMID: 39661665 Free PMC article.

2

Loss of wild type KRAS in KRAS^MUT lung adenocarcinoma is associated with cancer mortality and confers sensitivity to FASN inhibitors.

Liu Y, Gao GF, Minna JD, Williams NS, Westover KD. Liu Y, et al. Among authors: westover kd. Lung Cancer. 2021 Mar;153:73-80. doi: 10.1016/j.lungcan.2020.12.032. Epub 2021 Jan 2. Lung Cancer. 2021. PMID: 33465697 Free PMC article.

3

Therapeutic Targeting the Allosteric Cysteinome of RAS and Kinase Families.

Li L, Meyer C, Zhou ZW, Elmezayen A, Westover K. Li L, et al. J Mol Biol. 2022 Sep 15;434(17):167626. doi: 10.1016/j.jmb.2022.167626. Epub 2022 May 18. J Mol Biol. 2022. PMID: 35595166 Free PMC article. Review.

4

Lentiviral-Driven Discovery of Cancer Drug Resistance Mutations.

Yenerall P, Kollipara RK, Avila K, Peyton M, Eide CA, Bottomly D, McWeeney SK, Liu Y, Westover KD, Druker BJ, Minna JD, Kittler R. Yenerall P, et al. Among authors: westover kd. Cancer Res. 2021 Sep 15;81(18):4685-4695. doi: 10.1158/0008-5472.CAN-21-1153. Epub 2021 Jul 23. Cancer Res. 2021. PMID: 34301758 Free PMC article.

5

Torin2 Suppresses Ionizing Radiation-Induced DNA Damage Repair.

Udayakumar D, Pandita RK, Horikoshi N, Liu Y, Liu Q, Wong KK, Hunt CR, Gray NS, Minna JD, Pandita TK, Westover KD. Udayakumar D, et al. Among authors: westover kd. Radiat Res. 2016 May;185(5):527-38. doi: 10.1667/RR14373.1. Epub 2016 May 2. Radiat Res. 2016. PMID: 27135971 Free PMC article.

6

Progress on Covalent Inhibition of KRAS(G12C).

Westover KD, Jänne PA, Gray NS. Westover KD, et al. Cancer Discov. 2016 Mar;6(3):233-4. doi: 10.1158/2159-8290.CD-16-0092. Cancer Discov. 2016. PMID: 26951837

7

KRAS G12C Drug Development: Discrimination between Switch II Pocket Configurations Using Hydrogen/Deuterium-Exchange Mass Spectrometry.

Lu J, Harrison RA, Li L, Zeng M, Gondi S, Scott D, Gray NS, Engen JR, Westover KD. Lu J, et al. Among authors: westover kd. Structure. 2017 Sep 5;25(9):1442-1448.e3. doi: 10.1016/j.str.2017.07.003. Epub 2017 Aug 3. Structure. 2017. PMID: 28781083 Free PMC article.

8

Structure-Based Design of a Potent and Selective Covalent Inhibitor for SRC Kinase That Targets a P-Loop Cysteine.

Du G, Rao S, Gurbani D, Henning NJ, Jiang J, Che J, Yang A, Ficarro SB, Marto JA, Aguirre AJ, Sorger PK, Westover KD, Zhang T, Gray NS. Du G, et al. Among authors: westover kd. J Med Chem. 2020 Feb 27;63(4):1624-1641. doi: 10.1021/acs.jmedchem.9b01502. Epub 2020 Jan 30. J Med Chem. 2020. PMID: 31935084 Free PMC article.

9

Another KRAS variant trapped.

Westover K. Westover K. Nat Chem Biol. 2024 Sep;20(9):1096-1097. doi: 10.1038/s41589-024-01556-x. Nat Chem Biol. 2024. PMID: 38443471 No abstract available.

10

Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations.

Hunter JC, Manandhar A, Carrasco MA, Gurbani D, Gondi S, Westover KD. Hunter JC, et al. Among authors: westover kd. Mol Cancer Res. 2015 Sep;13(9):1325-35. doi: 10.1158/1541-7786.MCR-15-0203. Epub 2015 Jun 2. Mol Cancer Res. 2015. PMID: 26037647 Free article.

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