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Page 1
Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII.
Bonardi A, Falsini M, Catarzi D, Varano F, Di Cesare Mannelli L, Tenci B, Ghelardini C, Angeli A, Supuran CT, Colotta V. Bonardi A, et al. Eur J Med Chem. 2018 Feb 25;146:47-59. doi: 10.1016/j.ejmech.2018.01.033. Epub 2018 Jan 12. Eur J Med Chem. 2018. PMID: 29407972
2-Benzylpiperazine: A new scaffold for potent human carbonic anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents.
Chiaramonte N, Bua S, Ferraroni M, Nocentini A, Bonardi A, Bartolucci G, Durante M, Lucarini L, Chiapponi D, Dei S, Manetti D, Teodori E, Gratteri P, Masini E, Supuran CT, Romanelli MN. Chiaramonte N, et al. Among authors: bonardi a. Eur J Med Chem. 2018 May 10;151:363-375. doi: 10.1016/j.ejmech.2018.04.002. Epub 2018 Apr 3. Eur J Med Chem. 2018. PMID: 29635168
Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform.
Ibrahim HS, Allam HA, Mahmoud WR, Bonardi A, Nocentini A, Gratteri P, Ibrahim ES, Abdel-Aziz HA, Supuran CT. Ibrahim HS, et al. Among authors: bonardi a. Eur J Med Chem. 2018 May 25;152:1-9. doi: 10.1016/j.ejmech.2018.04.016. Epub 2018 Apr 10. Eur J Med Chem. 2018. PMID: 29684705
Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents.
Eldehna WM, Abo-Ashour MF, Nocentini A, El-Haggar RS, Bua S, Bonardi A, Al-Rashood ST, Hassan GS, Gratteri P, Abdel-Aziz HA, Supuran CT. Eldehna WM, et al. Among authors: bonardi a. Eur J Med Chem. 2019 Jan 15;162:147-160. doi: 10.1016/j.ejmech.2018.10.068. Epub 2018 Nov 2. Eur J Med Chem. 2019. PMID: 30445264
Novel Diamide-Based Benzenesulfonamides as Selective Carbonic Anhydrase IX Inhibitors Endowed with Antitumor Activity: Synthesis, Biological Evaluation and In Silico Insights.
Abdelrahman MA, Eldehna WM, Nocentini A, Bua S, Al-Rashood ST, Hassan GS, Bonardi A, Almehizia AA, Alkahtani HM, Alharbi A, Gratteri P, Supuran CT. Abdelrahman MA, et al. Among authors: bonardi a. Int J Mol Sci. 2019 May 20;20(10):2484. doi: 10.3390/ijms20102484. Int J Mol Sci. 2019. PMID: 31137489 Free PMC article.
Synthesis, biological evaluation and in silico studies with 4-benzylidene-2-phenyl-5(4H)-imidazolone-based benzenesulfonamides as novel selective carbonic anhydrase IX inhibitors endowed with anticancer activity.
Eldehna WM, Abdelrahman MA, Nocentini A, Bua S, Al-Rashood ST, Hassan GS, Bonardi A, Almehizia AA, Alkahtani HM, Alharbi A, Gratteri P, Supuran CT. Eldehna WM, et al. Among authors: bonardi a. Bioorg Chem. 2019 Sep;90:103102. doi: 10.1016/j.bioorg.2019.103102. Epub 2019 Jul 2. Bioorg Chem. 2019. PMID: 31299596
117 results