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Page 1
How to build the virtual cell with artificial intelligence: Priorities and opportunities.
Bunne C, Roohani Y, Rosen Y, Gupta A, Zhang X, Roed M, Alexandrov T, AlQuraishi M, Brennan P, Burkhardt DB, Califano A, Cool J, Dernburg AF, Ewing K, Fox EB, Haury M, Herr AE, Horvitz E, Hsu PD, Jain V, Johnson GR, Kalil T, Kelley DR, Kelley SO, Kreshuk A, Mitchison T, Otte S, Shendure J, Sofroniew NJ, Theis F, Theodoris CV, Upadhyayula S, Valer M, Wang B, Xing E, Yeung-Levy S, Zitnik M, Karaletsos T, Regev A, Lundberg E, Leskovec J, Quake SR. Bunne C, et al. Among authors: karaletsos t. Cell. 2024 Dec 12;187(25):7045-7063. doi: 10.1016/j.cell.2024.11.015. Cell. 2024. PMID: 39672099 Free article. Review.
EmbedGEM: a framework to evaluate the utility of embeddings for genetic discovery.
Mukherjee S, McCaw ZR, Pei J, Merkoulovitch A, Soare T, Tandon R, Amar D, Somineni H, Klein C, Satapati S, Lloyd D, Probert C; Insitro Research Team; Koller D, O'Dushlaine C, Karaletsos T. Mukherjee S, et al. Among authors: karaletsos t. Bioinform Adv. 2024 Sep 17;4(1):vbae135. doi: 10.1093/bioadv/vbae135. eCollection 2024. Bioinform Adv. 2024. PMID: 39664859 Free PMC article.
AI: A transformative opportunity in cell biology.
Carr A, Cool J, Karaletsos T, Li D, Lowe AR, Otte S, Schmid SL. Carr A, et al. Among authors: karaletsos t. Mol Biol Cell. 2024 Dec 1;35(12):pe4. doi: 10.1091/mbc.E24-09-0415. Mol Biol Cell. 2024. PMID: 39621362 Review.
How to Build the Virtual Cell with Artificial Intelligence: Priorities and Opportunities.
Bunne C, Roohani Y, Rosen Y, Gupta A, Zhang X, Roed M, Alexandrov T, AlQuraishi M, Brennan P, Burkhardt DB, Califano A, Cool J, Dernburg AF, Ewing K, Fox EB, Haury M, Herr AE, Horvitz E, Hsu PD, Jain V, Johnson GR, Kalil T, Kelley DR, Kelley SO, Kreshuk A, Mitchison T, Otte S, Shendure J, Sofroniew NJ, Theis F, Theodoris CV, Upadhyayula S, Valer M, Wang B, Xing E, Yeung-Levy S, Zitnik M, Karaletsos T, Regev A, Lundberg E, Leskovec J, Quake SR. Bunne C, et al. Among authors: karaletsos t. ArXiv [Preprint]. 2024 Oct 14:arXiv:2409.11654v2. ArXiv. 2024. Update in: Cell. 2024 Dec 12;187(25):7045-7063. doi: 10.1016/j.cell.2024.11.015 PMID: 39398201 Free PMC article. Updated. Preprint.
An allelic-series rare-variant association test for candidate-gene discovery.
McCaw ZR, O'Dushlaine C, Somineni H, Bereket M, Klein C, Karaletsos T, Casale FP, Koller D, Soare TW. McCaw ZR, et al. Among authors: karaletsos t. Am J Hum Genet. 2023 Aug 3;110(8):1330-1342. doi: 10.1016/j.ajhg.2023.07.001. Epub 2023 Jul 25. Am J Hum Genet. 2023. PMID: 37494930 Free PMC article.