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Page 1
Tailoring capsid directed evolution technology for improved AAV-mediated CAR-T generation.
Westhaus A, Barba-Sarasua E, Chen Y, Hsu K, Scott S, Knight M, Haase F, Mora SM, Houghton BC, Roca-Pinilla R, Kalajdzic P, O'Neill G, Thrasher AJ, Santilli G, Lisowski L. Westhaus A, et al. Among authors: lisowski l. Mol Ther. 2024 Dec 12:S1525-0016(24)00811-6. doi: 10.1016/j.ymthe.2024.12.012. Online ahead of print. Mol Ther. 2024. PMID: 39673125 Free article.
Codon-Optimization of Wild-Type Adeno-Associated Virus Capsid Sequences Enhances DNA Family Shuffling while Conserving Functionality.
Cabanes-Creus M, Ginn SL, Amaya AK, Liao SHY, Westhaus A, Hallwirth CV, Wilmott P, Ward J, Dilworth KL, Santilli G, Rybicki A, Nakai H, Thrasher AJ, Filip AC, Alexander IE, Lisowski L. Cabanes-Creus M, et al. Among authors: lisowski l. Mol Ther Methods Clin Dev. 2018 Nov 1;12:71-84. doi: 10.1016/j.omtm.2018.10.016. eCollection 2019 Mar 15. Mol Ther Methods Clin Dev. 2018. PMID: 30534580 Free PMC article.
High-Throughput In Vitro, Ex Vivo, and In Vivo Screen of Adeno-Associated Virus Vectors Based on Physical and Functional Transduction.
Westhaus A, Cabanes-Creus M, Rybicki A, Baltazar G, Navarro RG, Zhu E, Drouyer M, Knight M, Albu RF, Ng BH, Kalajdzic P, Kwiatek M, Hsu K, Santilli G, Gold W, Kramer B, Gonzalez-Cordero A, Thrasher AJ, Alexander IE, Lisowski L. Westhaus A, et al. Among authors: lisowski l. Hum Gene Ther. 2020 May;31(9-10):575-589. doi: 10.1089/hum.2019.264. Epub 2020 Feb 26. Hum Gene Ther. 2020. PMID: 32000541 Free PMC article.
Attenuation of Heparan Sulfate Proteoglycan Binding Enhances In Vivo Transduction of Human Primary Hepatocytes with AAV2.
Cabanes-Creus M, Westhaus A, Navarro RG, Baltazar G, Zhu E, Amaya AK, Liao SHY, Scott S, Sallard E, Dilworth KL, Rybicki A, Drouyer M, Hallwirth CV, Bennett A, Santilli G, Thrasher AJ, Agbandje-McKenna M, Alexander IE, Lisowski L. Cabanes-Creus M, et al. Among authors: lisowski l. Mol Ther Methods Clin Dev. 2020 May 13;17:1139-1154. doi: 10.1016/j.omtm.2020.05.004. eCollection 2020 Jun 12. Mol Ther Methods Clin Dev. 2020. PMID: 32490035 Free PMC article.
Novel human liver-tropic AAV variants define transferable domains that markedly enhance the human tropism of AAV7 and AAV8.
Cabanes-Creus M, Navarro RG, Zhu E, Baltazar G, Liao SHY, Drouyer M, Amaya AK, Scott S, Nguyen LH, Westhaus A, Hebben M, Wilson LOW, Thrasher AJ, Alexander IE, Lisowski L. Cabanes-Creus M, et al. Among authors: lisowski l. Mol Ther Methods Clin Dev. 2021 Nov 25;24:88-101. doi: 10.1016/j.omtm.2021.11.011. eCollection 2022 Mar 10. Mol Ther Methods Clin Dev. 2021. PMID: 34977275 Free PMC article.
AAV-p40 Bioengineering Platform for Variant Selection Based on Transgene Expression.
Westhaus A, Cabanes-Creus M, Jonker T, Sallard E, Navarro RG, Zhu E, Baltazar Torres G, Lee S, Wilmott P, Gonzalez-Cordero A, Santilli G, Thrasher AJ, Alexander IE, Lisowski L. Westhaus A, et al. Among authors: lisowski l. Hum Gene Ther. 2022 Jun;33(11-12):664-682. doi: 10.1089/hum.2021.278. Epub 2022 May 6. Hum Gene Ther. 2022. PMID: 35297686 Free PMC article.
Assessment of Pre-Clinical Liver Models Based on Their Ability to Predict the Liver-Tropism of Adeno-Associated Virus Vectors.
Westhaus A, Cabanes-Creus M, Dilworth KL, Zhu E, Salas Gómez D, Navarro RG, Amaya AK, Scott S, Kwiatek M, McCorkindale AL, Hayman TE, Frahm S, Perocheau DP, Tran BM, Vincan E, Wong SL, Waters SA, Riddiough GE, Perini MV, Wilson LOW, Baruteau J, Diecke S, González-Aseguinolaza G, Santilli G, Thrasher AJ, Alexander IE, Lisowski L. Westhaus A, et al. Among authors: lisowski l. Hum Gene Ther. 2023 Apr;34(7-8):273-288. doi: 10.1089/hum.2022.188. Hum Gene Ther. 2023. PMID: 36927149 Free PMC article.
Novel AAV variants with improved tropism for human Schwann cells.
Drouyer M, Chu TH, Labit E, Haase F, Navarro RG, Nazareth D, Rosin N, Merjane J, Scott S, Cabanes-Creus M, Westhaus A, Zhu E, Midha R, Alexander IE, Biernaskie J, Ginn SL, Lisowski L. Drouyer M, et al. Among authors: lisowski l. Mol Ther Methods Clin Dev. 2024 Mar 11;32(2):101234. doi: 10.1016/j.omtm.2024.101234. eCollection 2024 Jun 13. Mol Ther Methods Clin Dev. 2024. PMID: 38558569 Free PMC article.
Enhanced AAV transduction across preclinical CNS models: A comparative study in human brain organoids with cross-species evaluations.
Drouyer M, Merjane J, Nedelkoska T, Westhaus A, Scott S, Lee S, Burke PGR, McMullan S, Lanciego JL, Vicente AF, Bugallo R, Unzu C, González-Aseguinolaza G, Gonzalez-Cordero A, Lisowski L. Drouyer M, et al. Among authors: lisowski l. Mol Ther Nucleic Acids. 2024 Jun 28;35(3):102264. doi: 10.1016/j.omtn.2024.102264. eCollection 2024 Sep 10. Mol Ther Nucleic Acids. 2024. PMID: 39108635 Free PMC article.
116 results