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Regional action needed to halt antimalarial drug resistance in Africa.
Martinez-Vega R, Ishengoma DS, Gosling R, Rosenthal PJ, Dondorp A, Barnes KI, Nsanzabana C, Djimde AA, Ochola-Oyier LI, Tibenderana J, Chimumbwa J, Golassa L, Kapologwe NA, Mbacham WF, Kamya MR, Fidock DA, Komatsu R, von Seidlein L, Dhorda M. Martinez-Vega R, et al. Among authors: fidock da. Lancet. 2025 Jan 4;405(10472):7-10. doi: 10.1016/S0140-6736(24)02706-5. Epub 2024 Dec 12. Lancet. 2025. PMID: 39674185 No abstract available.
The emergence of artemisinin partial resistance in Africa: how do we respond?
Rosenthal PJ, Asua V, Bailey JA, Conrad MD, Ishengoma DS, Kamya MR, Rasmussen C, Tadesse FG, Uwimana A, Fidock DA. Rosenthal PJ, et al. Among authors: fidock da. Lancet Infect Dis. 2024 Sep;24(9):e591-e600. doi: 10.1016/S1473-3099(24)00141-5. Epub 2024 Mar 26. Lancet Infect Dis. 2024. PMID: 38552654 Review.
Determinants of piperaquine-resistant malaria in South America.
Mok S, Fidock DA. Mok S, et al. Among authors: fidock da. Lancet Infect Dis. 2024 Feb;24(2):114-116. doi: 10.1016/S1473-3099(23)00564-9. Epub 2023 Oct 16. Lancet Infect Dis. 2024. PMID: 37858324 Free PMC article. No abstract available.
Safety, tolerability, pharmacokinetics, and antimalarial activity of MMV533: a phase 1a first-in-human, randomised, ascending dose and food effect study, and a phase 1b Plasmodium falciparum volunteer infection study.
Bestgen B, Jones S, Thathy V, Kuemmerle A, Barcelo C, Haouala A, Gossen D, Marx MW, Di Resta I, Szramowska M, Webster RA, Llewellyn S, Ritacco DA, Yeo T, Leroy D, Barber BE, Fidock DA, Griffin P, Lickliter J, Chalon S. Bestgen B, et al. Among authors: fidock da. Lancet Infect Dis. 2024 Dec 18:S1473-3099(24)00664-9. doi: 10.1016/S1473-3099(24)00664-9. Online ahead of print. Lancet Infect Dis. 2024. PMID: 39708824 Free article.
Mixed alkyl/aryl phosphonates identify metabolic serine hydrolases as antimalarial targets.
Bennett JM, Narwal SK, Kabeche S, Abegg D, Thathy V, Hackett F, Yeo T, Li VL, Muir R, Faucher F, Lovell S, Blackman MJ, Adibekian A, Yeh E, Fidock DA, Bogyo M. Bennett JM, et al. Among authors: fidock da. Cell Chem Biol. 2024 Sep 19;31(9):1714-1728.e10. doi: 10.1016/j.chembiol.2024.07.006. Epub 2024 Aug 12. Cell Chem Biol. 2024. PMID: 39137783
Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3.
Calic PPS, Ashton TD, Mansouri M, Loi K, Jarman KE, Qiu D, Lehane AM, Roy S, Rao GP, Maity B, Wittlin S, Crespo B, Gamo FJ, Deni I, Fidock DA, Chowdury M, de Koning-Ward TF, Cowman AF, Jackson PF, Baud D, Brand S, Laleu B, Sleebs BE. Calic PPS, et al. Among authors: fidock da. Eur J Med Chem. 2024 Oct 5;276:116677. doi: 10.1016/j.ejmech.2024.116677. Epub 2024 Jul 14. Eur J Med Chem. 2024. PMID: 39024967 Free article.
Identification of the drug/metabolite transporter 1 as a marker of quinine resistance in a NF54×Cam3.II P. falciparum genetic cross.
Kanai M, Mok S, Yeo T, Shears MJ, Ross LS, Jeon JH, Narwal S, Haile MT, Tripathi AK, Mlambo G, Kim J, Gil-Iturbe E, Okombo J, Fairhurst KJ, Bloxham T, Bridgford JL, Sheth T, Ward KE, Park H, Rozenberg FD, Quick M, Mancia F, Lee MCS, Small-Saunders JL, Uhlemann AC, Sinnis P, Fidock DA. Kanai M, et al. Among authors: fidock da. bioRxiv [Preprint]. 2024 Oct 1:2024.09.27.615529. doi: 10.1101/2024.09.27.615529. bioRxiv. 2024. PMID: 39386571 Free PMC article. Preprint.
TKK130 is a 3-Hydroxy-Propanamidine (HPA) with Potent Antimalarial In Vivo Activity and a High Barrier to Resistance.
Knaab TC, Moritz A, Pessanha de Carvalho L, Klein S, Lungerich B, Lohse K, Kruse L, Mombo-Ngoma G, Orta L, Thibaud JL, de Villiers KA, Fidock DA, Burckhardt BB, Held J, Wittlin S, Kurz T. Knaab TC, et al. Among authors: fidock da. J Med Chem. 2025 Jan 9;68(1):95-107. doi: 10.1021/acs.jmedchem.4c01465. Epub 2024 Dec 26. J Med Chem. 2025. PMID: 39723908
Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b.
Awalt JK, Su W, Nguyen W, Loi K, Jarman KE, Penington JS, Ramesh S, Fairhurst KJ, Yeo T, Park H, Uhlemann AC, Chandra Maity B, De N, Mukherjee P, Chakraborty A, Churchyard A, Famodimu MT, Delves MJ, Baum J, Mittal N, Winzeler EA, Papenfuss AT, Chowdury M, de Koning-Ward TF, Maier AG, van Dooren GG, Baud D, Brand S, Fidock DA, Jackson PF, Cowman AF, Dans MG, Sleebs BE. Awalt JK, et al. Among authors: fidock da. Eur J Med Chem. 2024 Dec 15;280:116921. doi: 10.1016/j.ejmech.2024.116921. Epub 2024 Oct 3. Eur J Med Chem. 2024. PMID: 39388903 Free PMC article.
Novel hydrazone compounds with broad-spectrum antiplasmodial activity and synergistic interactions with antimalarial drugs.
Rosado-Quiñones AM, Colón-Lorenzo EE, Pala ZR, Bosch J, Kudyba K, Kudyba H, Leed SE, Roncal N, Baerga-Ortiz A, Roche-Lima A, Gerena Y, Fidock DA, Roth A, Vega-Rodríguez J, Serrano AE. Rosado-Quiñones AM, et al. Among authors: fidock da. Antimicrob Agents Chemother. 2024 Jun 5;68(6):e0164323. doi: 10.1128/aac.01643-23. Epub 2024 Apr 19. Antimicrob Agents Chemother. 2024. PMID: 38639491 Free PMC article.
303 results