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The primary mechanism for highly potent inhibition of HIV-1 maturation by lenacapavir.
Huang SW, Briganti L, Annamalai AS, Greenwood J, Shkriabai N, Haney R, Armstrong ML, Wempe MF, Singh SP, Francis AC, Engelman AN, Kvaratskhelia M. Huang SW, et al. Among authors: haney r. bioRxiv [Preprint]. 2024 Dec 7:2024.12.06.627250. doi: 10.1101/2024.12.06.627250. bioRxiv. 2024. PMID: 39677622 Free PMC article. Preprint.
The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir.
Dinh T, Tber Z, Rey JS, Mengshetti S, Annamalai AS, Haney R, Briganti L, Amblard F, Fuchs JR, Cherepanov P, Kim K, Schinazi RF, Perilla JR, Kim B, Kvaratskhelia M. Dinh T, et al. Among authors: haney r. bioRxiv [Preprint]. 2024 Jan 26:2024.01.26.577387. doi: 10.1101/2024.01.26.577387. bioRxiv. 2024. Update in: mBio. 2024 Nov 13;15(11):e0046524. doi: 10.1128/mbio.00465-24 PMID: 38328097 Free PMC article. Updated. Preprint.
Structural and Mechanistic Bases for Resistance of the M66I Capsid Variant to Lenacapavir.
Briganti L, Annamalai AS, Bester SM, Wei G, Andino-Moncada JR, Singh SP, Kleinpeter AB, Tripathi M, Nguyen B, Radhakrishnan R, Singh PK, Greenwood J, Schope LI, Haney R, Huang SW, Freed EO, Engelman AN, Francis AC, Kvaratskhelia M. Briganti L, et al. Among authors: haney r. bioRxiv [Preprint]. 2024 Nov 25:2024.11.25.625199. doi: 10.1101/2024.11.25.625199. bioRxiv. 2024. PMID: 39651162 Free PMC article. Preprint.
Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection.
Wei G, Iqbal N, Courouble VV, Francis AC, Singh PK, Hudait A, Annamalai AS, Bester S, Huang SW, Shkriabai N, Briganti L, Haney R, KewalRamani VN, Voth GA, Engelman AN, Melikyan GB, Griffin PR, Asturias F, Kvaratskhelia M. Wei G, et al. Among authors: haney r. Nat Commun. 2022 Oct 6;13(1):5879. doi: 10.1038/s41467-022-33662-6. Nat Commun. 2022. PMID: 36202818 Free PMC article.
Quinolinonyl Derivatives as Dual Inhibitors of the HIV-1 Integrase Catalytic Site and Integrase-RNA interactions.
Patacchini E, Madia VN, Albano A, Ruggieri G, Messore A, Ialongo D, Saccoliti F, Scipione L, Cosconati S, Koneru PC, Haney R, Kvaratskhelia M, Di Santo R, Costi R. Patacchini E, et al. Among authors: haney r. ACS Med Chem Lett. 2024 Aug 5;15(9):1533-1540. doi: 10.1021/acsmedchemlett.4c00268. eCollection 2024 Sep 12. ACS Med Chem Lett. 2024. PMID: 39291012
β-Carboline-3-carboxamide Antimalarials: Structure-Activity Relationship, ADME-Tox Studies, and Resistance Profiling.
Mathew J, Zhou B, Haney RS, Kunz KA, Do Amaral LS, Roy Chowdhury R, Butler JH, Li H, Chakraborty AJ, Tabassum A, Bremers EK, Merino EF, Coyle R, Lee MCS, Baud D, Brand S, Totrov M, Cassera MB, Carlier PR. Mathew J, et al. Among authors: haney rs. ACS Infect Dis. 2024 Nov 8;10(11):3951-3962. doi: 10.1021/acsinfecdis.4c00653. Epub 2024 Oct 28. ACS Infect Dis. 2024. PMID: 39466084
Differential Gene Expression following DHX36/G4R1 Knockout Is Associated with G-Quadruplex Content and Cancer.
Gumina JM, Richardson AE, Shojiv MH, Chambers AE, Sandwith SN, Reisinger MA, Karns TJ, Osborne TL, Alashi HN, Anderson QT, Sharlow ME, Seiler DC, Rogers EM, Bartosik AR, Smaldino MA, Vaughn JP, Wang YH, Smaldino PJ, Haney RA. Gumina JM, et al. Among authors: haney ra. Int J Mol Sci. 2024 Feb 1;25(3):1753. doi: 10.3390/ijms25031753. Int J Mol Sci. 2024. PMID: 38339029 Free PMC article.
98 results