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The hydrogen sulfide donor 4-carboxyphenyl-isothiocyanate decreases blood pressure and promotes cardioprotective effect through reduction of oxidative stress and nuclear factor kappa B/matrix metalloproteinase (MMP)-2 axis in hypertension.
Pernomian L, Blascke de Mello MM, Parente JM, Sanches-Lopes JM, Tanus-Santos JE, Parreiras E Silva LT, Antunes-Rodrigues J, da Conceição Dos Santos R, Elias LLK, Fabro AT, Silva CAA, Fazan R Jr, de Castro MM. Pernomian L, et al. Among authors: parreiras e silva lt. Life Sci. 2024 Aug 15;351:122819. doi: 10.1016/j.lfs.2024.122819. Epub 2024 Jun 8. Life Sci. 2024. PMID: 38857651
Hashtag bone: detrimental effects on bone contrast with metabolic benefits one and five years after Roux-en-Y gastric bypass.
Alencar MAVSD, Araújo IM, Parreiras-E-Silva LT, Nogueira-Barbosa MH, Salgado W Jr, Elias J Jr, Salmon CEG, Paula FJA. Alencar MAVSD, et al. Among authors: parreiras e silva lt. Braz J Med Biol Res. 2021 Dec 3;54(12):e11499. doi: 10.1590/1414-431X2021e11499. eCollection 2021. Braz J Med Biol Res. 2021. PMID: 34878062 Free PMC article.
BRET-based effector membrane translocation assay monitors GPCR-promoted and endocytosis-mediated Gq activation at early endosomes.
Wright SC, Lukasheva V, Le Gouill C, Kobayashi H, Breton B, Mailhot-Larouche S, Blondel-Tepaz É, Antunes Vieira N, Costa-Neto C, Héroux M, Lambert NA, Parreiras-E-Silva LT, Bouvier M. Wright SC, et al. Among authors: parreiras e silva lt. Proc Natl Acad Sci U S A. 2021 May 18;118(20):e2025846118. doi: 10.1073/pnas.2025846118. Proc Natl Acad Sci U S A. 2021. PMID: 33990469 Free PMC article.
Novel potent (dihydro)benzofuranyl piperazines as human histamine receptor ligands - Functional characterization and modeling studies on H3 and H4 receptors.
Corrêa MF, Balico-Silva AL, Kiss DJ, Fernandes GAB, Maraschin JC, Parreiras-E-Silva LT, Varela MT, Simões SC, Bouvier M, Keserű GM, Costa-Neto CM, Fernandes JPS. Corrêa MF, et al. Among authors: parreiras e silva lt. Bioorg Med Chem. 2021 Jan 15;30:115924. doi: 10.1016/j.bmc.2020.115924. Epub 2020 Dec 8. Bioorg Med Chem. 2021. PMID: 33333448
29 results