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Disrupted uromodulin trafficking is rescued by targeting TMED cargo receptors.
Bazua-Valenti S, Brown MR, Zavras J, Riedl Khursigara M, Grinkevich E, Sidhom EH, Keller KH, Racette M, Dvela-Levitt M, Quintanova C, Demirci H, Sewerin S, Goss AC, Lin J, Yoo H, Vaca Jacome AS, Papanastasiou M, Udeshi N, Carr SA, Himmerkus N, Bleich M, Mutig K, Bachmann S, Halbritter J, Kmoch S, Živná M, Kidd K, Bleyer AJ, Weins A, Alper SL, Shaw JL, Kost-Alimova M, Pablo JLB, Greka A. Bazua-Valenti S, et al. Among authors: mutig k. J Clin Invest. 2024 Dec 16;134(24):e180347. doi: 10.1172/JCI180347. J Clin Invest. 2024. PMID: 39680459 Free PMC article.
Hyperkalemia and blood pressure regulation.
Mutig K, Bachmann S. Mutig K, et al. Nephrol Dial Transplant. 2019 Dec 1;34(Suppl 3):iii26-iii35. doi: 10.1093/ndt/gfz218. Nephrol Dial Transplant. 2019. PMID: 31800077 Review.
Annexin A2 mediates apical trafficking of renal Na⁺-K⁺-2Cl⁻ cotransporter.
Dathe C, Daigeler AL, Seifert W, Jankowski V, Mrowka R, Kalis R, Wanker E, Mutig K, Bachmann S, Paliege A. Dathe C, et al. Among authors: mutig k. J Biol Chem. 2014 Apr 4;289(14):9983-97. doi: 10.1074/jbc.M113.540948. Epub 2014 Feb 13. J Biol Chem. 2014. PMID: 24526686 Free PMC article.
Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3.
McCormick JA, Yang CL, Zhang C, Davidge B, Blankenstein KI, Terker AS, Yarbrough B, Meermeier NP, Park HJ, McCully B, West M, Borschewski A, Himmerkus N, Bleich M, Bachmann S, Mutig K, Argaiz ER, Gamba G, Singer JD, Ellison DH. McCormick JA, et al. Among authors: mutig k. J Clin Invest. 2014 Nov;124(11):4723-36. doi: 10.1172/JCI76126. Epub 2014 Sep 24. J Clin Invest. 2014. PMID: 25250572 Free PMC article.
62 results